1.220 makale bulundu

Parkinson Hastalığında Otofaji Süreci GBA1 ve LRRK2 Genlerindeki Mutasyonlara Bağlıdır.

Autophagy Process in Parkinson's Disease Depends on Mutations in the GBA1 and LRRK2 Genes.

Bezrukova AI, Basharova KS, Emelyanov AK, Rybakov AV, Miliukhina IV, Pchelina SN, Usenko TS.

Biochem Genet · 2025-05-19

DOI: 10.1007/s10528-025-11125-zPMID: 40388077

Orta beyin dopamin nöronlarının moleküler ve uzamsal transkriptomik sınıflandırması ve bir LRRK2<sup>G2019S</sup> Parkinson hastalığının modeli.

Molecular and spatial transcriptomic classification of midbrain dopamine neurons and their alterations in a LRRK2<sup>G2019S</sup> model of Parkinson's disease.

Gaertner Z, Oram C, Schneeweis A, Schonfeld E, Bolduc C, Chen C, Dombeck D, Parisiadou L, Poulin JF, Awatramani R.

Elife · 2025-05-12

DOI: 10.7554/elife.101035PMID: 40353820

Leucine-Rich Repeat Kinase 2 (LRRK2) Proteininin Modülasyonu ile Otozomal Parkinson Hastalığının Terapötik Hedeflenmesi.

Therapeutic Targeting of Autosomal Parkinson's Disease by Modulation of Leucine-Rich Repeat Kinase 2 (LRRK2) Protein.

Hyderi Z, Farhana M S, Singh TP, Ravi AV.

Brain Res · 2025-05-08

DOI: 10.1016/j.brainres.2025.149674PMID: 40345365

Dopamin D2 reseptörü dorsal striatumda LRRK2-R1441C sıçan modelinde in vivo PET görüntüleme ile ortaya çıkan erken Parkinson hastalığı.

Dopamine D2 receptor upregulation in dorsal striatum in the LRRK2-R1441C rat model of early Parkinson's disease revealed by in vivo PET imaging.

Delgado-Goñi T, Connor-Robson N, Cioroch M, Paisey S, Marshall C, Lane EL, Hauton D, McCullagh J, Magill PJ, Cragg SJ, Mackay CE, Wade-Martins R, Klein JC.

Sci Rep · 2025-05-07

DOI: 10.1038/s41598-025-99580-xPMID: 40335575

Emergent glutamate & dopamine dysfunction in VPS35<sub>(D620N)</sub> knock-in mice and rapid reversal by LRRK2 inhibition.

Kamesh A, Kadgien CA, Kuhlmann N, Coady S, Pietrantonio A, Cousineau Y, Khayachi A, Jurado Santos A, Hurley EP, Barron JC, Parsons MP, Milnerwood AJ.

NPJ Parkinsons Dis · 2025-05-03

DOI: 10.1038/s41531-025-00948-7PMID: 40319043

Parkinson hastalığı olan hastalarda LRRK2 ve GBA varyantlarının ortostatik hipotansiyona etkisi.

Impact of LRRK2 and GBA variants on orthostatic hypotension in patients with Parkinson's disease.

Liu W, Han Y, Liu Y, Tian M, Liu H, Yang Y, Liu J, Song C, Liu Y.

J Neurol · 2025-05-02

DOI: 10.1007/s00415-025-13086-0PMID: 40314780

LRRK2- ile ilişkili Parkinson hastalığında ⁇ -sinüklein oligomerlerinin yaygın dağılımı.

Widespread distribution of α-synuclein oligomers in LRRK2-related Parkinson's disease.

Sekiya H, Franke L, Hashimoto Y, Takata M, Nishida K, Futamura N, Hasegawa K, Kowa H, Ross OA, McLean PJ, Toda T, Wszolek ZK, Dickson DW.

Acta Neuropathol · 2025-05-02

DOI: 10.1007/s00401-025-02872-9PMID: 40314842

[Parkinson's Disease Associated with Mutations in the LRRK2 Gene: Approaches to Therapy].

Usenko TS, Pchelina SN.

Mol Biol (Mosk) · 2025-05-01

DOI: 10.31857/s0026898425030024PMID: 40864855

Parkinson Hastalığında LRRK2 nadir değişkenli alan başına genetik yük: kinaz etki alanı ile sınırlı ilişki.

LRRK2 rare-variant per-domain genetic burden in Parkinson's Disease: association confined to the kinase domain.

Parlar SC, Senkevich K, Yu E, Ruskey JA, Ahmad J, Asayesh F, Spiegelman D, Waters C, Monchi O, Dauvilliers Y, Dupré N, Greenbaum L, Hassin-Baer S, Miliukhina I, Timofeeva A, Emelyanov A, Pchelina S, Alcalay RN, Fon EA, Trempe JF, Gan-Or Z.

NPJ Parkinsons Dis · 2025-04-29

DOI: 10.1038/s41531-025-00934-zPMID: 40301370

Lizozomal TPC2 kanalları, LRRK2-Parkinson hastalığının modellerinde Ca2+ girişini ve dopaminerjik fonksiyonunu bozar.

Lysosomal TPC2 channels disrupt Ca2+ entry and dopaminergic function in models of LRRK2-Parkinson's disease.

Gregori M, Pereira GJS, Allen R, West N, Chau KY, Cai X, Bostock MP, Bolsover SR, Keller M, Lee CY, Lei SH, Harvey K, Bracher F, Grimm C, Hasan G, Gegg ME, Schapira AHV, Sweeney ST, Patel S.

J Cell Biol · 2025-04-25

DOI: 10.1083/jcb.202412055PMID: 40279672

Parkinson Hastalığında LRRK2'nin Çok Yönlü Rolü.

The Multifaceted Role of LRRK2 in Parkinson's Disease.

Ho DH, Han SJ, Son I.

Brain Sci · 2025-04-17

DOI: 10.3390/brainsci15040407PMID: 40309866

Çevresel Faktörler Asya'ya Özel Bir Knock-In LRRK2 Risk Varyantında Parkinson Fenotiplerini Sürdürür.

Environmental Factors Exacerbate Parkinsonian Phenotypes in an Asian-Specific Knock-In LRRK2 Risk Variant in Mice.

Bichler Z, Vanan S, Zhang Z, Dong QS, Lee JWL, Zhang C, Hang L, Jiang M, Padmanabhan P, Saw WT, Zhou Z, Gulyás B, Lim KL, Zeng L, Tan EK.

Int J Mol Sci · 2025-04-10

DOI: 10.3390/ijms26083556PMID: 40332013