1.289 makale bulundu

Parkinson Hastalığında Nükleer Alfa-Synüklein ve Melanomda Malign Dönüşüm.

Nuclear Alpha-Synuclein in Parkinson's Disease and the Malignant Transformation in Melanoma.

Jimenez-Capdeville ME, Chi-Ahumada E, García-Ortega F, Castanedo-Cazares JP, Norman R, Rodríguez-Leyva I.

Neurol Res Int · 2025-01-06

DOI: 10.1155/nri/1119424PMID: 39816956

Imaging Alpha-synuclein with Novel 5<i>H</i>-Imidazo[1,5-<i>b</i>][1,2,4]triazole Radioligands for the Diagnosis of Parkinson's Disease.

Song Z, Liang SH.

ACS Med Chem Lett · 2025-01-06

DOI: 10.1021/acsmedchemlett.4c00607PMID: 39967619

Novel Heterocyclic Piperazine Amide Derivatives as Alpha-synuclein PET Ligands for Diagnosis of Parkinson's Disease.

Li Y, Liang SH.

ACS Med Chem Lett · 2025-01-06

DOI: 10.1021/acsmedchemlett.4c00606PMID: 39967640

Parkinson Hastalığında Alkaloidlerin Alfa-sinüklein Toksisitesine Karşı Koruyucu Etkilerinin Bir İncelemesi.

A Review of the Protective Effects of Alkaloids against Alpha-synuclein Toxicity in Parkinson's Disease.

Khodadadi M, Javadi B.

Mini Rev Med Chem · 2025-01-01

DOI: 10.2174/0113895575306884240604065754PMID: 38874050

Aşamalı Tarama Nöronal Alfa-Synüklein Hastalığı ile İlgili Biyobelirteçli İnsanları Tanımlar.

Staged Screening Identifies People with Biomarkers Related to Neuronal Alpha-Synuclein Disease.

Brown EG, Chahine LM, Siderowf A, Gochanour C, Kurth R, Marshall MJ, Caspell-Garcia C, Brumm MC, Stanley CE, Korell M, McMahon B, Kuhl M, Fabrizio K, Heathers L, Concha-Marambio L, Soto C, Chowdhury S, Coffey CS, Foroud TM, Simuni T, Marek K, Tanner CM, Parkinson Progression Marker Initiative.

Ann Neurol · 2024-12-24

DOI: 10.1002/ana.27158PMID: 39719857

Parkinson Hastalığında Mitokondrial Kalite Kontrolüne Alfa-Synüklein Etkileri.

Alpha-Synuclein Effects on Mitochondrial Quality Control in Parkinson's Disease.

Shen L, Dettmer U.

Biomolecules · 2024-12-22

DOI: 10.3390/biom14121649PMID: 39766356

BCKDK kaybı mitokondriyal Kompleks I aktivitesini bozar ve Parkinson hastalığı modellerinde alfa-sinüklein agregasyonuna neden olur.

BCKDK loss impairs mitochondrial Complex I activity and drives alpha-synuclein aggregation in models of Parkinson's disease.

Jishi A, Hu D, Shang Y, Wang R, Gunzler SA, Qi X.

Acta Neuropathol Commun · 2024-12-21

DOI: 10.1186/s40478-024-01915-8PMID: 39709505

Parkinson hastalığı hastalarının gastroduodenal ve cilt biyopsilerinde alfa-sinüklein RT-QuIC tahlili.

Alpha-synuclein RT-QuIC assay in gastroduodenal and skin biopsies of Parkinson disease patients.

Emmi A, Mammana A, Sandre M, Baiardi S, Weis L, Rossi M, Magliocchetti F, Savarino E, Russo FP, Porzionato A, Carecchio M, Campagnolo M, Antonini A, Parchi P.

Ann Clin Transl Neurol · 2024-12-21

DOI: 10.1002/acn3.52282PMID: 39708331

Düzeltme: Parkinson hastalığı risk geni katepsin B, dopaminerjik nöronlarda fibriler alfa-sinüklein klirensi, lizozomal fonksiyon ve glukocerebrosidaz aktivitesini teşvik eder.

Correction: The Parkinson's disease risk gene cathepsin B promotes fibrillar alpha-synuclein clearance, lysosomal function and glucocerebrosidase activity in dopaminergic neurons.

Jones-Tabah J, He K, Karpilovsky N, Senkevich K, Deyab G, Pietrantonio I, Goiran T, Cousineau Y, Nikanorova D, Goldsmith T, Del Cid Pellitero E, Chen CX, Luo W, You Z, Abdian N, Ahmad J, Ruskey JA, Asayesh F, Spiegelman D, Fahn S, Waters C, Monchi O, Dauvilliers Y, Dupré N, Miliukhina I, Timofeeva A, Emelyanov A, Pchelina S, Greenbaum L, Hassin-Baer S, Alcalay RN, Milnerwood A, Durcan TM, Gan-Or Z, Fon EA.

Mol Neurodegener · 2024-12-18

DOI: 10.1186/s13024-024-00791-zPMID: 39696367

Astrositler, insan orta beyin Parkinson modelinde toll benzeri reseptör 2-ortalı nörodejenerasyon ve alfa-sinüklein patolojisine katkıda bulunur.

Astrocytes contribute to toll-like receptor 2-mediated neurodegeneration and alpha-synuclein pathology in a human midbrain Parkinson's model.

Weiss F, Hughes L, Fu Y, Bardy C, Halliday GM, Dzamko N.

Transl Neurodegener · 2024-12-16

DOI: 10.1186/s40035-024-00448-3PMID: 39681872

Alpha-synuclein-induced upregulation of SKI family transcriptional corepressor 1: A new player in aging and Parkinson's disease?

Barrett L, Bevans R, Sullivan AM, Collins LM, O'Keeffe GW.

Neural Regen Res · 2024-12-16

DOI: 10.4103/nrr.nrr-d-24-01156PMID: 39688564

Parkinson hastalığında bağışıklık temelli alfa-sinüklein denemeleri hakkında bir güncelleme.

An update on immune-based alpha-synuclein trials in Parkinson's disease.

Alfaidi M, Barker RA, Kuan WL.

J Neurol · 2024-12-12

DOI: 10.1007/s00415-024-12770-xPMID: 39666171