14.046 makale bulundu

Triprolidine Interferes with α-Synuclein Fibrillation and Remodels Aggregate Structure via Conformational Modulation.

Hassan MN, Hussain M, Nabi F, Singh D, Yasmeen S, Zafar MS, Rizvi I, Zakariya SM, Siddiqui WA, Uversky VN, Khan RH.

Biochemistry · 2026-08-27

DOI: 10.1021/acs.biochem.6c00571PMID: 42689912

Clinical and Genetic Spectrum of <i>ATP1A3</i>-Related Disorders: A Multicenter Cross-Sectional Study.

Rebelo Procaci V, da Hora RPC, Gomes AM, Silva TYT, Embiruçu EK, Silva TO, Van Der Linden V, Estephan EP, Oliveira FN, de Goes FV, de Freitas MR, Horovitz DDG, Domingues JDP, Möller PDDS, Poswar FO, Krueger MB, van der Linden H, Torres BR, Loutfi KS, Kauark RBG, Inuzuka LM, Cabral KSS, Oliveira I, Rocha MSG, Camargos S, Maia DP, Maciel ROH, Cardoso F, da Penha Ananias Morita M, Coelho ÉN, França MC, Lima PLGSB, Pessoa ALS, Barsottini OGP, Nóbrega PR, Pedroso JL, as the ATP1A3 Study Group.

Neurol Genet · 2026-08-27

DOI: 10.1212/nxg.0000000000200429PMID: 42666683

Aquaporin-4 mis-localization decreases glymphatic clearance of α-synuclein in an alpha-syntrophin knock out mouse model and promotes α-synuclein pathology and aggregate propagation.

Aquaporin-4 yanlış lokalizasyon, alfa-sintrofin bir fare modelinde ⁇ -sinükleinin glimfatik klirensini azaltır ve ⁇ -sinüklein patolojisini ve agrega yayılımını teşvik eder.

Braun M, Simon MJ, Jang J, Sanderson K, Swierz J, Sevao M, Pincus AB, Schaser AJ, Elliott JE, Lim MM, Unni VK, Schindler AG, Keene CD, Latimer CS, Iliff JJ.

Brain Commun · 2026-08-26

DOI: 10.1093/braincomms/fcag327PMID: 42712833

Human DOPA Decarboxylase in Monoamine Metabolism, Pharmacology, and Synucleinopathies.

Chiasserini D, Bellomo G, Orvietani PL, Dindo M.

ACS Bio Med Chem Au · 2026-08-26

DOI: 10.1021/acsbiomedchemau.6c00141PMID: 42921305

Clinical utility of skin biopsy detection of phosphorylated alpha-synuclein in an outpatient practice.

Levine T, Freeman R, Murray N, Swanson A, Gibbons CT, Crowell J, Phillips J, Gibbons CH.

Front Neurol · 2026-08-25

DOI: 10.3389/fneur.2026.1868980PMID: 42712504

Motor System Neurodegeneration in Aging and Synucleinopathies: Circuit Vulnerability and Neuroimaging Biomarkers.

Wen J, Xu X, Ge Y.

Aging Dis · 2026-08-25

DOI: 10.14336/ad.2026.0457PMID: 42691220

LRRK2: Molecular Mechanisms in Parkinson's Disease.

Arias-Carrión O, Guerra-Crespo M, Ortuño-Sahagún D, Ortega-Robles E.

Int J Mol Sci · 2026-08-25

DOI: 10.3390/ijms27177606PMID: 42737506

Divergent tau pathology profiles induced by distinct alpha-synuclein aggregates in non-human primates.

Darricau M, Neu-Faber C, Bourdenx M, Dovero S, Porras G, Thiolat ML, Trigo-Damas I, Garcia-Carrillo N, Herrero MT, Vila M, Obeso JA, Planche V, Bezard E, Dehay B.

Brain · 2026-08-22

DOI: 10.1093/brain/awag284PMID: 42631513

Quantifying the Acute Toxicity of Alpha-Synuclein Membrane-Accumulation in a Cell-Based Assay.

Li B, Anderson AK, Alnakhala H, Levy OA, Ramalingam N, Dettmer U.

J Mol Neurosci · 2026-08-22

DOI: 10.1007/s12031-026-02578-xPMID: 42631812

α-Synuclein Forms Distinct Micelle-Like Assemblies at Low Ionic Strengths.

Hertel S, Ray S, Saraceno F, Nisini G, Nasi G, Mason TO, Kunka A, Agrimaki E, Olesen DJ, Ruggeri FS, Buell AK.

Adv Sci (Weinh) · 2026-08-21

DOI: 10.1002/advs.77300PMID: 42627558

Glucocerebrosidase dysfunction in GBA1 carriers: insights from blood and macrophage analyses.

Nikolaev M, Kopytova A, Izyumchenko A, Senkevich K, Artynyuk A, Pidyurchina V, Baydakova G, Miliukhina I, Zakharova E, Emelyanov A, Pchelina S.

Mol Biol Rep · 2026-08-21

DOI: 10.1007/s11033-026-12610-3PMID: 42627573

Effects of α-Synuclein on the Lipid Phenotype of SZ95 Human Sebocytes: A Preliminary Study in the Context of Parkinson's Disease.

Mosca S, Bottillo G, Flori E, Kovacs D, Maiellaro M, Lozzi F, Cavallo A, Zouboulis CC, Simmini G, Luppino A, Novello C, Leta V, Gaudiano G, Devigili G, Eleopra R, Tagliavini F, Mazzetti S, Camera E, Cardinali G.

Cells · 2026-08-21

DOI: 10.3390/cells15161505PMID: 42645231