1.289 makale bulundu

Parkinson Hastalığı Patogenezinde Sinfilin-1 ve Alfa-Synüklein Etkileşiminin Yapısal Proteomik Araştırması.

A Structural Proteomics Exploration of Synphilin-1 and Alpha-Synuclein Interaction in Pathogenesis of Parkinson's Disease.

Tripathi A, Mondal R, Mandal M, Lahiri T, Pal MK.

Biomolecules · 2024-12-12

DOI: 10.3390/biom14121588PMID: 39766295

Temel bir amino asit olan Taurin, alfa-sinüklein agregasyonunu inhibe ederek ve dopamin salınımını arttırarak farelerde rotenon kaynaklı Parkinson hastalığını zayıflatır.

Taurine, an essential amino acid, attenuates rotenone-induced Parkinson's disease in rats by inhibiting alpha-synuclein aggregation and augmenting dopamine release.

Onuelu JE, Ben-Azu B, Adebayo OG, Fokoua AR, Nekabari MK, Ozah EO, Iwhiwhu P, Ajayi AM, Oyovwi OM, Omogbiy IA, Eduviere AT, Ojezele MO.

Behav Brain Res · 2024-12-12

DOI: 10.1016/j.bbr.2024.115397PMID: 39674372

Intranasal administration of tissue inhibitor of metalloproteinase 1 extracted from stem cells from human exfoliated deciduous teeth-conditioned medium improves neurological outcomes and alpha-synuclein elimination in Parkinson's disease mice.

Chen YN, Chen YR, Yang BH, Lee PH, Kuo LT, Li CH.

J Dent Sci · 2024-12-12

DOI: 10.1016/j.jds.2024.11.029PMID: 40224104

Parkinson Hastalığında Amiloid Formasyonuna Karşı Potansiyel Bir Terapötik Zayıflatıcı Olarak Cimetidin Keşfetmek: Alfa-Synüklein ve İnsan İnsülinine Spektroskopik ve Mikroskopik Öngörüler.

Exploring Cimetidine as a Potential Therapeutic Attenuator against Amyloid Formation in Parkinson's Disease: Spectroscopic and Microscopic Insights into Alpha-Synuclein and Human Insulin.

Hassan MN, Ahmad A, Hussain M, Gupta S, Khan HY, Aziz T, Khan RH.

ACS Chem Neurosci · 2024-12-04

DOI: 10.1021/acschemneuro.4c00588PMID: 39628315

Alzheimer, Parkinson ve Lewy cisimleriyle demansta otoantikor profiller: hastalığa özgü patolojik paternlerde alfa-sinüklein, amiloid-beta ve tau'ya değiştirilmiş IgG afinite ve IgG / IgM / IgA yanıtları.

Autoantibody profiles in Alzheimer´s, Parkinson´s, and dementia with Lewy bodies: altered IgG affinity and IgG/IgM/IgA responses to alpha-synuclein, amyloid-beta, and tau in disease-specific pathological patterns.

Knecht L, Dalsbøl K, Simonsen AH, Pilchner F, Ross JA, Winge K, Salvesen L, Bech S, Hejl AM, Løkkegaard A, Hasselbalch SG, Dodel R, Aznar S, Waldemar G, Brudek T, Folke J.

J Neuroinflammation · 2024-12-03

DOI: 10.1186/s12974-024-03293-3PMID: 39627772

Autophagy Deficits Underly Selective Neuronal Vulnerability to Alpha Synuclein Fibrils in Alzheimer’s and Parkinson’s iPSC Derived Neurons

Abey A, Ng B, Heon‐Roberts R, Carlyle B, Bengoa‐Vergniory N, Wade‐Martins R.

Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024-12-01

Characterization and Evaluation of Alpha‐Synuclein Aggregates: Unveiling Their Potential as a Biomarker for Parkinson's Disease (PD)

Debarnot C, Challagundla M, Kleinert C, Schulz M, Henn C, Boehm N, Richter M.

Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024-12-01

Serum Alpha‐Synuclein and Inflammatory Markers profile in an Egyptian Alzheimer’s and Parkinson’s Diseases patients: A Pilot Study

Heikal S.

Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024-12-01

MJF-14 yakınlık ligasyonu tahlili, erken inklüzyon olmayan alfa-sinüklein patolojisini gelişmiş özgüllük ve hassasiyetle tespit eder.

MJF-14 proximity ligation assay detects early non-inclusion alpha-synuclein pathology with enhanced specificity and sensitivity.

Jensen NM, Fu Y, Betzer C, Li H, Elfarrash S, Shaib AH, Krah D, Vitic Z, Reimer L, Gram H, Buchman V, Denham M, Rizzoli SO, Halliday GM, Jensen PH.

NPJ Parkinsons Dis · 2024-11-29

DOI: 10.1038/s41531-024-00841-9PMID: 39613827

Parkinson Hastalığında Alfa-Synüklein ve Mikroglia: Patogenezden Terapötik Beklentilere.

Alpha-Synuclein and Microglia in Parkinson's Disease: From Pathogenesis to Therapeutic Prospects.

Eo H, Kim S, Jung UJ, Kim SR.

J Clin Med · 2024-11-28

DOI: 10.3390/jcm13237243PMID: 39685702

Alfa-sinüklein Fibriller Depresyon ile Parkinson Hastalığı Benzeri Değişiklikleri İndüklemek için mPFC'de BDNF / ERK Sinyal Döngüsünün Aktivasyonunu İnhibe Ediyor.

Alpha-synuclein Fibrils Inhibit Activation of the BDNF/ERK Signaling Loop in the mPFC to Induce Parkinson's Disease-like Alterations with Depression.

Ma Z, Xu Y, Lian P, Wu Y, Liu K, Zhang Z, Tang Z, Yang X, Cao X.

Neurosci Bull · 2024-11-28

DOI: 10.1007/s12264-024-01323-xPMID: 39609371

Parkinson hastalığı risk geni katepsin B, dopaminerjik nöronlarda fibriller alfa-sinüklein klirensi, lizozomal fonksiyon ve glukoserebrosidaz aktivitesini teşvik eder.

The Parkinson's disease risk gene cathepsin B promotes fibrillar alpha-synuclein clearance, lysosomal function and glucocerebrosidase activity in dopaminergic neurons.

Jones-Tabah J, He K, Karpilovsky N, Senkevich K, Deyab G, Pietrantonio I, Goiran T, Cousineau Y, Nikanorova D, Goldsmith T, Del Cid Pellitero E, Chen CX, Luo W, You Z, Abdian N, Ahmad J, Ruskey JA, Asayesh F, Spiegelman D, Fahn S, Waters C, Monchi O, Dauvilliers Y, Dupré N, Miliukhina I, Timofeeva A, Emelyanov A, Pchelina S, Greenbaum L, Hassin-Baer S, Alcalay RN, Milnerwood A, Durcan TM, Gan-Or Z, Fon EA.

Mol Neurodegener · 2024-11-25

DOI: 10.1186/s13024-024-00779-9PMID: 39587654