14.182 makale bulundu

Inflammation and neuropsychiatric symptoms in Parkinson's disease: a genetic association.

Gonçalves AR, Mendes A, Damásio J, Vila-Chã N, Boleixa D, Santos C, Leal B, Cavaco S.

Front Aging Neurosci · 2026-08-31

DOI: 10.3389/fnagi.2026.1877657PMID: 42741404

Rebalancing α-Synuclein Clearance: Novel Therapeutic Frontiers in Parkinson's Disease.

Jabeen M, Hameed H, Ahmad SM, Mushtaq T, Khan MA, Hameed A.

Neuromolecular Med · 2026-08-31

DOI: 10.1007/s12017-026-08948-3PMID: 42675202

Clearance and secretion of α-synuclein by RTN3L-mediated endoplasmic reticulum autophagy.

Ye Y, Kumar K, Xu Y, Xu F, Ferro-Novick S.

Mol Biol Cell · 2026-08-31

DOI: 10.1091/mbc.e26-03-0138PMID: 42455619

Kokulu proteomikler, HDAC1 inhibitörü pirokamidinin, nazal epitel, mikroglial ve dopaminerjik nöronal hücre hatlarında ⁇ -sinüklein önceden oluşturulmuş fibrillerin neden olduğu hasarı durdurma kapasitesini ortaya koymaktadır.

Olfactory proteomics reveals the capacity of the HDAC1 inhibitor pyroxamide to halt the α-synuclein preformed fibrils-induced damage in nasal epithelial, microglial and dopaminergic neuronal cell lines.

Cartas-Cejudo P, De Miguel M, Extramiana L, Lachén-Montes M, Romero-Murillo S, Gveric D, Fernández-Irigoyen J, Santamaría E.

Brain Pathol · 2026-08-30

DOI: 10.1111/bpa.70140PMID: 42669843

Polyamine metabolic enzyme SAT1 remodels the neuronal transcriptome and rescues α-synuclein toxicity in Drosophila.

Bangash ZR, Matsui H, Ranxhi B, Todi SV, LeWitt PA, Tsou WL.

Amino Acids · 2026-08-30

DOI: 10.1007/s00726-026-03544-yPMID: 42734829

From viral epigenetic reprogramming to neuroinflammation: Mechanisms driving neurodegeneration.

Vora C, Saini V, Shevtsov M, Trivedi P, Sonawane A, Jha HC.

J Neurovirol · 2026-08-27

DOI: 10.1007/s13365-026-01341-7PMID: 42661118

Triprolidine Interferes with α-Synuclein Fibrillation and Remodels Aggregate Structure via Conformational Modulation.

Hassan MN, Hussain M, Nabi F, Singh D, Yasmeen S, Zafar MS, Rizvi I, Zakariya SM, Siddiqui WA, Uversky VN, Khan RH.

Biochemistry · 2026-08-27

DOI: 10.1021/acs.biochem.6c00571PMID: 42689912

Clinical and Genetic Spectrum of <i>ATP1A3</i>-Related Disorders: A Multicenter Cross-Sectional Study.

Rebelo Procaci V, da Hora RPC, Gomes AM, Silva TYT, Embiruçu EK, Silva TO, Van Der Linden V, Estephan EP, Oliveira FN, de Goes FV, de Freitas MR, Horovitz DDG, Domingues JDP, Möller PDDS, Poswar FO, Krueger MB, van der Linden H, Torres BR, Loutfi KS, Kauark RBG, Inuzuka LM, Cabral KSS, Oliveira I, Rocha MSG, Camargos S, Maia DP, Maciel ROH, Cardoso F, da Penha Ananias Morita M, Coelho ÉN, França MC, Lima PLGSB, Pessoa ALS, Barsottini OGP, Nóbrega PR, Pedroso JL, as the ATP1A3 Study Group.

Neurol Genet · 2026-08-27

DOI: 10.1212/nxg.0000000000200429PMID: 42666683

Backbone Thioamide Substitution Enhances the Activity of Short Peptides in Modulating the Aggregation of α-Synuclein

Zheng H, Miller K, Ivanova MI, Newberry RW.

· 2026-08-26

DOI: 10.64898/2026.08.25.746879

Aquaporin-4 yanlış lokalizasyon, alfa-sintrofin bir fare modelinde ⁇ -sinükleinin glimfatik klirensini azaltır ve ⁇ -sinüklein patolojisini ve agrega yayılımını teşvik eder.

Aquaporin-4 mis-localization decreases glymphatic clearance of α-synuclein in an alpha-syntrophin knock out mouse model and promotes α-synuclein pathology and aggregate propagation.

Braun M, Simon MJ, Jang J, Sanderson K, Swierz J, Sevao M, Pincus AB, Schaser AJ, Elliott JE, Lim MM, Unni VK, Schindler AG, Keene CD, Latimer CS, Iliff JJ.

Brain Commun · 2026-08-26

DOI: 10.1093/braincomms/fcag327PMID: 42712833

Human DOPA Decarboxylase in Monoamine Metabolism, Pharmacology, and Synucleinopathies.

Chiasserini D, Bellomo G, Orvietani PL, Dindo M.

ACS Bio Med Chem Au · 2026-08-26

DOI: 10.1021/acsbiomedchemau.6c00141PMID: 42921305

Sex- and age-dependent energetic dysfunction in LRRK2 G2019S Parkinson’s model revealed by structural analysis of RGC dendritic architecture and metabolic profiling of optic nerve

Cimaglia G, Tribble JR, Williams PA, Morgan JE, Votruba M, Beccano-Kelly D.

· 2026-08-25

DOI: 10.21203/rs.3.rs-10550625/v1