14.182 makale bulundu

Multi-omics analysis reveals coordinated epigenetic dysregulation in atrazine-induced dopaminergic neurotoxicity.

Ning S, Liu Z, Li Y, Zhang R.

Food Chem Toxicol · 2026-08-15

DOI: 10.1016/j.fct.2026.116339PMID: 42600914

alfa-Synüklein Parkinson Hastalığında Patolojiyi Sürdürmek İçin Ras ⁇ PI3K / AKT / mTOR Sinyallemesini Etkinleştirir

α-Synuclein Activates Ras–PI3K/AKT/mTOR Signaling to Drive Pathology in Parkinson’s Disease

Abd-Elhadi S, Congdon-Loeffler J, Naamneh L, Khatib D, Harrosch E, Maya OBR, Eliassaf A, Shalev O, Sharon R.

· 2026-08-14

DOI: 10.21203/rs.3.rs-10524137/v1

Hücre dışı vezikülle ilişkili alfa-sinüklein alıcı nöronlarda retrograd sinyalizasyon-endozom kaçakçılığını bozar

Extracellular vesicle-associated α-synuclein disrupts retrograde signalling-endosome trafficking in recipient neurons

Meunier F, Duda B, Saber S, Lanoue V, Ghebosu R, Bademosi A, Gormal R, Matthews B, Wallis T, McCann A, Abosnwber Y, Cooper-White J, Verstreken P, Spiers J, Vassileff N, Anderson W, Krishnakumar A, Antaw F, Trau M, Wolfram J.

· 2026-08-14

DOI: 10.21203/rs.3.rs-10572966/v1

<i>GCH1</i> genetic variation as a prognostic factor in Parkinson’s disease across populations

Shin JH, Periñan MT, Jang JW, Screven L, Lange LM, Klein C, Shulman JM, Gan-Or Z, Shahkhali MG, Senkevich K, Dusek P, Miliukhina I, Alcalay RN, Lin C, Wu R, Morris HR, Tan E, Zhang B, Cogan G, Brice A, Mencacci NE, Sarmiento IJK, Simuni T, Sassi SB, Martí MJ, Pastor P, Tay YW, Tan AH, Lim S, Stamelou M, Chafota F, Rentería ME, Mohamed W, Mata IF, Cornejo Olivas M, Cesarini M, Rivera A, Avenali M, Valente EM, Foroud TM, Nudelman KNH, Brumm MC, Gasser T, Weil RS, Shepherd C, Kumar KR, Krüger R, Marek K, Kaiyrzhanov R, Gentleman S, Lee J, Kim H, Jeon B, the Global Parkinson’s Genetics Program (GP2).

· 2026-08-14

DOI: 10.64898/2026.08.14.26359677

Plazma alfa-sinüklein ve Parkinson hastalığında QSM kaynaklı duyarlılık: klinik özelliklerle ilişkiler.

Plasma α-synuclein and QSM-derived susceptibility in Parkinson's disease: associations with clinical features.

Li X, Luo T, Bai J.

Front Aging Neurosci · 2026-08-14

DOI: 10.3389/fnagi.2026.1740309PMID: 42666293

alfa-Synüklein suşu çoklu sistem atrofi alt tiplerinde homojenlik.

α-Synuclein strain homogeneity in multiple system atrophy subtypes.

Lau HHC, Silver NRG, Mehra S, So RWL, Li LY, Mao A, Stuart E, Schmitt-Ulms C, Hyman BT, Ingelsson M, Watts JC.

Brain Pathol · 2026-08-14

DOI: 10.1111/bpa.70134PMID: 42601815

Birden fazla sistem atrofi türevi alfa-sinüklein fibrilleri daha güçlüdür ve Parkinson hastalığı türevi fibrillere kıyasla oligodendrosit hücre tropizmi gösterir.

Multiple system atrophy-derived α-synuclein fibrils are more potent and display oligodendrocyte cell tropism compared to Parkinson's disease-derived fibrils.

Laursen AS, Willén K, Fenyi A, Volbracht C, Dalgaard LT, Aznar S, Melki R, Fog K, Sotty F.

Neurobiol Dis · 2026-08-14

DOI: 10.1016/j.nbd.2026.107575PMID: 42600994

Chaperone Clusterin Parkinson hastalığı beyninde alfa-Synüklein nöropatolojisine katılır.

The chaperone Clusterin participates in α-Synuclein neuropathology in Parkinson’s disease brain

Pizzi S, Zanchi G, Calogero AM, Mazzetti S, Filippini A, Carini G, Mutti V, Ramazzina I, Cimignolo I, Corti C, Volta M, Calandrella D, Rolando C, Russo I, Pezzoli G, Cappelletti G.

· 2026-08-13

DOI: 10.21203/rs.3.rs-10625001/v1

Benzothiazole-driven molecular probes and therapeutics for neurodegenerative diseases: focus on amyloid-beta (Aβ), tau, and α-synuclein.

Kumar N, Khan I, Singh J, Kumar K, Kushwaha VK, Kumar S, Ojha S, Dash AK, Shankar G.

RSC Med Chem · 2026-08-13

DOI: 10.1039/d6md00462hPMID: 42662146

Hücre dışı veziküllerin LRRK2 ve Rab GTPases tarafından lizozomal stres altında subtipe özgü salgılanması.

Subtype-specific secretion of extracellular vesicles by LRRK2 and Rab GTPases under lysosomal stress.

Sakurai M, Kuwahara T, Suenaga S, Takatori S, Tomita T, Shalit T, Tengstrand E, Hsieh F, Iwatsubo T.

iScience · 2026-08-13

DOI: 10.1016/j.isci.2026.117203PMID: 42630748

Up-regulation of the kinase LRRK2, in enteric glia contributes to mucosal barrier impairment in Parkinson's disease via secretory autophagy.

D'Antongiovanni V, Pierucci C, Segnani C, Ippolito C, Di Salvo C, Lucarini E, Antonioli L, Fornai M, Bernardini N, Derkinderen P, Scarpignato C, Pellegrini C.

Br J Pharmacol · 2026-08-13

DOI: 10.1111/bph.70623PMID: 42593416

⁇ i>de novo GBA ⁇ /i> ile ilişkili Parkinson hastalığında kortikal ve subkortikal morfolojik değişiklikler.

Cortical and subcortical morphological alterations in &lt;i&gt;de novo GBA&lt;/i&gt;-related Parkinson's disease.

Ren J, Xing Y, Zhou H, Hong X, Huang X, Liu W.

Front Aging Neurosci · 2026-08-12

DOI: 10.3389/fnagi.2026.1885255PMID: 42656384