14.182 makale bulundu

Cutaneous alpha-synuclein deposition informs autonomic function in individuals with early-stage multiple system atrophy.

Trujillo P, Mann L, Bellaire B, Freeman R, Levine T, Gibbons CH, Cooper A, Wong C, Stamler D, Claassen DO.

Clin Auton Res · 2026-08-12

DOI: 10.1007/s10286-026-01235-yPMID: 42587236

Pathological Mutation E46K Acts as an Electrostatic Switch to Increase Distant Interdomain Interactions and Promote α‑Synuclein Phase Separation.

Yang Z, Tang Y, Wen J, Guo C, Zhou Y, Wang Z, Pan T, Tan Y, Perrett S, Wu S, Wei G.

JACS Au · 2026-08-12

DOI: 10.1021/jacsau.6c00631PMID: 42656830

Parkinson hastalığında nitratlı alfa-sinüklein spesifik CAR-Treg tedavisinin preklinik değerlendirmesi.

Preclinical evaluation of nitrated α-synuclein-specific CAR-Treg therapy in Parkinson's disease.

Ugalde V, Elgueta D, Espinoza S, Chovar-Vera O, López E, Catenaccio A, Álvarez-Astudillo F, Franz D, Sanchez-Guajardo V, Becker MI, Figueroa D, Manjarres Z, Hidalgo S, Lladser Á, Tapia-Rojas C, Loyola A, Quezada SA, Villagra R, Pacheco R.

Cell Rep Med · 2026-08-12

DOI: 10.1016/j.xcrm.2026.102983PMID: 42586065

Structural basis of α-synuclein and DJ-1 complex.

Kim HJ, Kim DH, Han CW, Jeong MS, Jang SB.

Int J Biol Macromol · 2026-08-12

DOI: 10.1016/j.ijbiomac.2026.154021PMID: 42586342

Epigenetic drift and LINE-1 activation in aging brain: Implications for neurodegenerative disease.

Armoundas AA, Piperi C.

Mech Ageing Dev · 2026-08-11

DOI: 10.1016/j.mad.2026.112235PMID: 42580558

Early-Onset Parkinson's Disease with 22q11.2 Microdeletion and Pathogenic GBA1 Variant.

Reyes NGD, Luca DGD, Martinez-Valbuena I, Boot E, Corral M, Yuen RKC, Marras C, Lang AE, Bassett AS.

Mov Disord Clin Pract · 2026-08-10

DOI: 10.1002/mdc3.70772PMID: 42572960

G51D ⁇ -sinüklein farelerde birincil silia ve nörotrofik sinyalin seçici kaybı Parkinson hastalığına ortak bir yolu vurgulamaktadır.

Selective loss of primary cilia and neurotrophic signaling in G51D α-synuclein mice highlights a common pathway to Parkinson's disease.

Lin YE, Jaimon E, Kim Y, Loftman A, Vijayakumaran A, Belfort BDW, Chiang CY, Arenkiel BR, Zoghbi HY, Pfeffer SR.

Proc Natl Acad Sci U S A · 2026-08-10

DOI: 10.1073/pnas.2619797123PMID: 42574603

LRRK2'nin aktivasyonu ve otoenhibisyonu için yapısal temel.

The structural basis for LRRK2's activation and autoinhibition.

Villagran Suarez A, Hatch KS, Bodrug T, Gai W, Surridge KJ, Moussikhina E, Nguyen KHV, Sanz-Murillo M, Callahan R, Xiong E, Ramos D, Zhu L, Dederer V, Mathea S, Iwasa J, Knapp S, Shokat KM, Reck-Peterson SL, Leschziner AE.

Cell · 2026-08-10

DOI: 10.1016/j.cell.2026.07.027PMID: 42575089

Sinüklein eksikliği, beyindeki lipit peroksidasyonunda bir değişikliğe neden olur.

Lack of synucleins induces an alteration of lipid peroxidation in the brain.

Fedulina AA, Seryogina ES, Chaprov KD, Baev AY, Vinokurov AY, Abramov AY.

Biochem Biophys Res Commun · 2026-08-10

DOI: 10.1016/j.bbrc.2026.154420PMID: 42594814

Chemogenetic activation and inhibition of CaMKⅡα-positive neurons in the dorsal hippocampus modulate spatial working memory and hippocampus-dependent memory in the hemiparkinsonian rat.

Wang XC, Liu J, Qiu ZH, Guo Y, Hu H, Li F, Chen L, Zhang L.

Neurochem Int · 2026-08-10

DOI: 10.1016/j.neuint.2026.106237PMID: 42570797

Attenuating LRRK2 activity ameliorates progerin-induced aging phenotypes in HGPS models and during physiological aging

Mann L, Rodriguez RH, van der Walt F, Brimacombe KR, Sadouki S, Misteli T, Kubben N, Padeken J.

· 2026-08-07

DOI: 10.64898/2026.08.04.742751

Kortikostriyal terminallerde alfa-Synüklein agregaları, nörodejenerasyon yokluğunda glutamaterjik iletimi bozar

α-Synuclein aggregates in corticostriatal terminals impair glutamatergic transmission in the absence of neurodegeneration

Brzozowski CF, Fokakis ZN, Menard MA, Challa HV, Gallardo I, Hall JD, Narbert D, Millet M, Hardaway JA, Moehle MS, Volpicelli-Daley LA.

· 2026-08-07

DOI: 10.64898/2026.08.03.742532