14.182 makale bulundu

<i>GBA1</i> variants and mortality in Parkinson's disease: A systematic review and meta-analysis.

Chan N, Raphael A, Kim J, Haryanto A, Heshmat S, Khoo TK.

J Parkinsons Dis · 2026-08-07

DOI: 10.1177/1877718x261470604PMID: 42565774

Effect of genetic factors on [<sup>18</sup>F]FDG PET metabolic phenotypes in dementia with Lewy bodies.

Lövdal S, Meles SK, Carli G, Dortmond A, Kogan RV, Goldstein O, Gana-Weisz M, Orad RI, Alcalay RN, Bregman N, Leenders KL, Shiner T.

Eur J Nucl Med Mol Imaging · 2026-08-07

DOI: 10.1007/s00259-026-08124-6PMID: 42566020

Identification of comprehensive genetic factors, pathways, and shared genetic architecture of putamen volume in adolescent cohort.

Singh A, Posner J.

Transl Psychiatry · 2026-08-07

DOI: 10.1038/s41398-026-04299-6PMID: 42816494

Akkermansia muciniphila gavage alleviates depression-like behaviors in female A53T α-synuclein transgenic mice.

Li S, Chu X, Deng R, Zheng W, Suo X, Sun G, Liu H, Geng M, Tian J, Zhang Y.

Behav Brain Res · 2026-08-07

DOI: 10.1016/j.bbr.2026.116413PMID: 42567327

The m6A RNA methylation exerts a neuroprotective function by regulating the expression of α-synuclein

Chen X, Zhao T, Zhang F, Ran Y, Duan J, Wang J, Liu Z.

· 2026-08-06

DOI: 10.21203/rs.3.rs-10238426/v1

Alpha-synuclein targets retinal rod ribbon synapse by disrupting synaptic vesicle dynamics and mitochondrial integrity: Reversal by 40 Hz green-light flicker

Xu T, Li X, Wang T, Zhang X, Sun Z, Shao D, Zhang J, Yang Y, Xiao Z, Zhang Y, Wang X, Guo W, He Y, Zhu S, Zhang Y, Jin Z, Shen M, Zhang X, Liu J, Lv F, Qu J, Chen J.

· 2026-08-06

DOI: 10.21203/rs.3.rs-10254179/v1

Şilili bir kohortta Parkinson Hastalığının genetik karakterizasyonu

Genetic characterization of Parkinson’s Disease in a Chilean cohort

Saffie-Awad P, Crea PW, Grant S, Lee PS, Leal TP, Teixeira-dos-Santos D, Akçimen F, Khani M, Waldo E, Pizarro-Correa X, Solís-Añez E, Blauwendraat C, Singleton A, Klein C, Bandres-Ciga S, Mata IF, Inca-Martínez M, Schuh AFS, Chaná-Cuevas P.

· 2026-08-06

DOI: 10.64898/2026.08.04.26358901

REM sleep behavior disorder and synucleinopathies.

Uzma N, Wajdi M, Alhashmi A, Qatanany B, Sharafkhaneh A, Kosagisharaf JR, Nami M.

Prog Brain Res · 2026-08-06

DOI: 10.1016/bs.pbr.2026.07.009PMID: 42711026

Lack of genetic evidence for a role of SLC25A46 in alpha-synucleinopathies.

Yu H, Parlar SC, Senkevich K, Somerville EN, Zhang Z, Liu L, Teferra M, Ahmad J, Asayesh F, Rouleau GA, Gan-Or Z.

J Parkinsons Dis · 2026-08-06

DOI: 10.1177/1877718x261452773PMID: 42558006

LRRK2, aktin sitoskelet dinamiğinin modülasyonu yoluyla sinaptik fonksiyonu düzenler.

LRRK2 regulates synaptic function through modulation of actin cytoskeletal dynamics.

Tombesi G, Kompella S, Favetta G, Chen C, Ornaghi M, Zhao Y, Morosin E, Sevegnani M, Lama A, Marte A, Battisti I, Iannotta L, Plotegher N, Civiero L, Onofri F, Eickholt BJ, Piccoli G, Arrigoni G, Beccano-Kelly D, Manzoni C, Parisiadou L, Greggio E.

Elife · 2026-08-06

DOI: 10.7554/elife.95987PMID: 42559947

Kolesterol, GBA L444P mutasyonlu Parkinson hastalığında daha iyi alfa-sinüklein klerensi için lizozom-otofagozom füzyonunu arttırır.

Cholesterol enhances lysosome-autophagosome fusion for better α-synuclein clearance in GBA L444P-mutated Parkinson disease.

Chen M, Liu F, Yang Y, Chen R, Gan L, Sun Y, Yan Y, Xie S, Zhu C, Sun X, Li Y, Zhu S, Liu W, Zuo J, Yang Y, Wang J.

Cell Rep · 2026-08-06

DOI: 10.1016/j.celrep.2026.117800PMID: 42560815

alfa-Synüklein, Parkinson hastalığının erken dönemlerinde endoplazmik retikulum ko-translasyonel protein translokasyonunu bloke eder.

α-Synuclein blocks endoplasmic reticulum co-translational protein translocation early in Parkinson's disease.

Lam CL, Gatford NJF, Aragón-González A, Tanudjojo B, Sahoo A, Castle AR, Agarwal D, Jainarayanan A, Hester SS, Sen N, Benesch JLP, Fischer R, Sims D, Tofaris GK.

Nat Commun · 2026-08-06

DOI: 10.1038/s41467-026-76173-4PMID: 42562827