14.182 makale bulundu

Alzheimer nöropatolojik değişimi, çocuklarda 43 kDa ekspresyonunun ⁇ -sinüklein ve transaktif yanıt DNA bağlayıcı proteini ve adli otopsilerden genç yetişkin beyinleri: Nörodejeneratif hastalıklarda anormal protein ekspresyon prevalansının erken ölçümü için değer.

Alzheimer neuropathological change, α-synuclein and transactive response DNA-binding protein of 43 kDa expression in children and young adult brains from forensic autopsies: Value for early measurement of abnormal protein expression prevalence in neurodegenerative diseases.

Calderón-Garcidueñas L, Nalbantoglu OU, González-Maciel A, Torres-Jardón R.

J Neuropathol Exp Neurol · 2026-08-01

DOI: 10.1093/jnen/nlag028PMID: 42008720

Alpha-Synuclein-Specific RT-QuIC As a Tool for the Differential Diagnosis of Neurodegenerative Diseases Using Peripheral Tissues.

Ix M, Dodel R, Ross JA.

Clin Chem · 2026-08-01

DOI: 10.1093/clinchem/hvag037PMID: 42184266

Parkinson Bozukluklarının Küresel Kohortunda Patoloji ve Genetik.

Pathology and Genetics in a Global Cohort of Parkinsonian Disorders.

Wu LY, du Toit T, Georgiades T, Stafford EJ, Levine K, Fang ZH, Jasaityte S, Martinez AG, Cullinane P, De Pablo-Fernandez E, Blauwendraat C, Singleton AB, Scholz SW, Traynor BJ, Wood N, Hardy J, Chinnery P, Houlden H, Cain R, Troakes C, Chelban V, Serrano GE, Gveric D, McLean C, Love S, King A, Robinson AC, Roncaroli F, Shepherd C, Halliday G, Parkkinen L, Morris CM, Smith C, Beach TG, Gentleman S, Warner TT, Lashley T, Jaunmuktane Z, Real R, Morris HR, Global Parkinson’s Genetic Program (GP2).

JAMA Neurol · 2026-08-01

DOI: 10.1001/jamaneurol.2026.1634PMID: 42258190

An important step towards delineating Parkinson's disease genetics worldwide.

Bonifati V.

Lancet Neurol · 2026-08-01

DOI: 10.1016/s1474-4422(26)00232-2PMID: 42456668

Parkinson hastalığı genetiği çeşitli ansestlerde: nedensel ve risk varyantlarının çevirisel etkileri olan gözlemsel bir genetik çalışması.

Parkinson's disease genetics across diverse ancestries: an observational genetic study of causal and risk variants with translational implications.

Lange LM, Fang ZH, Makarious MB, Kuznetsov N, Atterling Brolin K, Ballard S, Bardien S, Doquenia ML, Heutink P, Houlden H, Iwaki H, Jasaityte S, Jones L, Junker J, Kaiyrzhanov R, Koretsky MJ, Kumar KR, Latin American Research Consortium on the Genetics of Parkinson's Disease (LARGE-PD), Leonard HL, Levine KS, Lim SY, Mencacci NE, Mohamed WMY, Nalls MA, Noyce AJ, Ojha R, Okubadejo NU, Ur Rehman S, Screven L, Shashkin C, Sopromadze S, Stafford EJ, Tan AH, Tan M, Tavadyan Z, Trinh J, Tserensodnom B, Valente EM, Vitale D, Zharkinbekova N, Lohmann K, Bandres-Ciga S, Blauwendraat C, Singleton AB, Morris HR, Klein C, Global Parkinson's Genetics Program (GP2).

Lancet Neurol · 2026-08-01

DOI: 10.1016/s1474-4422(26)00198-5PMID: 42456684

Heterojunction-Mediated Dual-Site Synergistic Catalysis for Enhanced Electrochemiluminescence Detection of α-Synuclein.

Li Y, Dong X, Wu T, Ren X, Du Y, Ju H, Wei Q.

Anal Chem · 2026-08-01

DOI: 10.1021/acs.analchem.6c02862PMID: 42479881

G2019S LRRK2 Kinase Inhibition in Heterozygous Mice Avoids Lung Phenotype Observed with Inhibition of WT LRRK2.

Garofalo AW, Schonemann MD, Santoro M, Zhao J, Nichols RJ, Montine TJ.

ACS Chem Neurosci · 2026-08-01

DOI: 10.1021/acschemneuro.6c00147PMID: 42503786

Parkinson Hastalığında Bilişsel İşlev Bozukluğunun Temellendirilmesi: Güncel Kanıtlar ve Gelecek Beklentileri.

Epigenetic Mechanisms Underlying Cognitive Dysfunction in Parkinson's Disease: Current Evidence and Future Prospects.

Hasani F, Kherad ME, Sarasyabi MS, Jazi K, Ashkbari A, Ahmadi P, Heidarpour H, Masrour M, Khamaki S, Rahmati R, Surguchov A.

Brain Behav · 2026-08-01

DOI: 10.1002/brb3.71602PMID: 42528277

Transgenik A53T Fareler Dopamin ve Striatal Bölgelerde Astrositik alfa-Sinüklein Agregatlarına sahiptir.

Transgenic A53T Mice Have Astrocytic α-Synuclein Aggregates in Dopamine and Striatal Regions.

Peat C, Prasad A, Finkelstein DI, Sue C, Johnston JA, Parish CL, Thompson L, Kirik D, Halliday GM.

Neuropathol Appl Neurobiol · 2026-08-01

DOI: 10.1111/nan.70097PMID: 42608961

[Peripheral Autonomic Neuropathy in α-Synucleinopathy].

Yagita K, Takao M.

Brain Nerve · 2026-08-01

DOI: 10.11477/mf.188160960780080889PMID: 42609146

Genetik Parkinson Hastalığı Modelinde Mitokondriyal Fonksiyonel Modülasyon ile Arginin Zenginleştirilmiş Penetratin Peptid Konfeksiyonunun İntranazal Uygulaması.

Intranasal Administration of an Arginine-Enriched Penetratin Peptide Confers Neuroprotection via Mitochondrial Functional Modulation in a Genetic Parkinson's Disease Model.

Chang JC, Yeh CY, Liu KL, Chao YC, Lin CH, Liu CS.

CNS Neurosci Ther · 2026-08-01

DOI: 10.1002/cns.71108PMID: 42644489

Parkinson hastalığında düşen kırılganlığın çift bozulma modelinde dorsomedial striatal dopamin tükenmesinden sonra bazal forebrain kolinerjik nöronların optogenetik inhibisyonu ile indüklenen düşmeler.

Falls induced by optogenetic inhibition of basal forebrain cholinergic neurons after dorsomedial striatal dopamine depletion in a dual disruption model of falling vulnerability in Parkinson's disease.

Kucinski A.

Behav Brain Res · 2026-08-01

DOI: 10.1016/j.bbr.2026.116409PMID: 42542273