Açık erişim
Intensive multidisciplinary rehabilitation modulates serum <i>α</i>-synuclein and miRNA expression in Parkinson's disease: preliminary results of a randomized study.
Agostini S, Meloni M, Mancuso R, Nuzzi R, Ferraro G, Salvatore A, Arcuri P, Castagna A, Navarro J, Saibene FL, Clerici M.
Front Cell Neurosci · 2026-05-28
DOI: 10.3389/fncel.2026.1760593PMID: 42290958
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Açık erişim
Genetic variation in antidiabetic drug targets: associations with Parkinson's disease risk and age at onset.
Vincze K, Szwajda A, Ploner A, Karlsson R, Kang X, Tang B, Qin C, Domenighetti C, Sugier PE, Ashok Kumar Sreelatha A, Schulte C, Portugal B, May P, Bobbili DR, Radivojkov-Blagojevic M, Lichtner P, Singleton AB, Hernandez DG, Edsall C, Mellick GD, Zimprich A, Pirker W, Rogaeva E, Lang AE, Koks S, Taba P, Lesage S, Brice A, Corvol JC, Chartier-Harlin MC, Mutez E, Brockmann K, Deutschlander AB, Burbulla LF, Hadjigeorgiou GM, Dardiotis E, Stefanis L, Simitsi AM, Valente EM, Petrucci S, Straniero L, Zecchinelli A, Pezzoli G, Brighina L, Ferrarese C, Annesi G, Quattrone A, Gagliardi M, Matsuo H, Nakayama A, Hattori N, Nishioka K, Chung SJ, Kim YJ, Kolber P, Van de Warrenburg BP, Bloem BR, Toft M, Pihlstrøm L, Correia Guedes L, Ferreira JJ, Bardien S, Carr J, Tolosa E, Ezquerra M, Pastor P, Ran C, Belin AC, Puschmann A, Clarke CE, Morrison KE, Tan M, Krainc D, Farrer MJ, Landoulsi Z, Kruger R, Gasser T, Elbaz A, Sharma M, Pedersen NL, Carlsson S, Hägg S, Wirdefeldt K, Comprehensive Unbiased Risk Factor Assessment for Genetics and Environment in Parkinson’s Disease (COURAGE-PD) Consortium, Domenighetti C, Sugier PE, Ashok Kumar Sreelatha A, Schulte C, Portugal B, May P, Bobbili DR, Radivojkov-Blagojevic M, Lichtner P, Singleton AB, Hernandez DG, Edsall C, Mellick GD, Zimprich A, Pirker W, Rogaeva E, Lang AE, Koks S, Taba P, Lesage S, Brice A, Corvol JC, Chartier-Harlin MC, Mutez E, Brockmann K, Deutschlander AB, Burbulla LF, Hadjigeorgiou GM, Dardiotis E, Stefanis L, Simitsi AM, Valente EM, Petrucci S, Straniero L, Zecchinelli A, Pezzoli G, Brighina L, Ferrarese C, Annesi G, Quattrone A, Gagliardi M, Matsuo H, Nakayama A, Hattori N, Nishioka K, Chung SJ, Kim YJ, Kolber P, Van de Warrenburg BP, Bloem BR, Toft M, Pihlstrøm L, Correia Guedes L, Ferreira JJ, Bardien S, Carr J, Tolosa E, Ezquerra M, Pastor P, Ran C, Belin AC, Puschmann A, Clarke CE, Morrison KE, Tan M, Krainc D, Farrer MJ, Landoulsi Z, Kruger R, Gasser T, Elbaz A, Sharma M, Wirdefeldt K.
NPJ Parkinsons Dis · 2026-05-28
DOI: 10.1038/s41531-026-01398-5PMID: 42209523
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Açık erişim
A human <i>GBA-L444P</i> transgene drives early and persistent dopamine neurotransmission deficits and alpha-synuclein pathology in a mouse model of early Parkinson’s disease
Connor-Robson N, Diviney T, Alegre-Abarrategui J, Roberts B, Brimblecombe KR, Bengoa-Vergniory N, Waters H, Cioroch M, Davies B, Bila KO, van der Lienden MJC, Aerts JMFG, Cragg S, Wade-Martins R.
· 2026-05-27
DOI: 10.64898/2026.05.25.727583
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Kaynak kaydı
Genetically Encoded Constitutive Upregulation of β2 Subunit-Containing Neuronal Nicotinic Acetylcholine Receptors Is Neuroprotective in Female Parkinsonian Mice.
Pandey G, Garcia RC, Das D, Mohan AR, Rodriguez C, Pollock D, Karthik N, Nalluri S, Nguyen T, Polo C, Zarate SM, Rimer M, Srinivasan R.
J Neurosci · 2026-05-27
DOI: 10.1523/jneurosci.1368-25.2026PMID: 42049511
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Kaynak kaydı
The PET tracer [<sup>11</sup>C]MODAG-005 targets alpha-synuclein aggregates in the brain.
Saw RS, Haas S, Schmidt F, Ryazanov S, Leonov A, Bleher D, Grotegerd AK, Kuebler L, Roeben B, Schmidt F, Reimold M, Bonanno F, Ruf VC, Dahl B, Sandiego CM, Henry KE, Papadopoulos I, Schaller M, Kahle PJ, Levin J, Gasser T, Brockmann K, Reischl G, la Fougère C, Pichler BJ, Maurer A, Griesinger C, Giese A, Herfert K.
Sci Transl Med · 2026-05-27
DOI: 10.1126/scitranslmed.aec0813PMID: 42202047
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Açık erişim
Inter-assay and Inter-site Performance of Alpha-Synuclein Seed Amplification Assays in Synucleinopathies: A Multicenter 2 × 2 Protocol Comparison.
Plaza-Clar R, Weber M, Kadam V, Deuschle C, Ma Y, Farris CM, Concha-Marambio L, Mengel D, Rossi M, Mammana A, Parchi P, Synofzik M, Brockmann K, Gasser T.
Neurol Ther · 2026-05-27
DOI: 10.1007/s40120-026-00965-5PMID: 42201636
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