1.220 makale bulundu

LRRK2 G2019S Parkinson hastalığı idiyopatikten daha iyi huylu fenotipli.

LRRK2 G2019S Parkinson's disease with more benign phenotype than idiopathic.

Ben Romdhan S, Farhat N, Nasri A, Lesage S, Hdiji O, Ben Djebara M, Landoulsi Z, Stevanin G, Brice A, Damak M, Gouider R, Mhiri C.

Acta Neurol Scand · 2018-07-10

DOI: 10.1111/ane.12996PMID: 29989150

Han Çin popülasyonunda Parkinson hastalığında LRRK2'nin genetik analizi.

Genetic analysis of LRRK2 in Parkinson's disease in Han Chinese population.

Zhang JR, Jin H, Li K, Mao CJ, Yang YP, Wang F, Gu CC, Zhang HJ, Chen J, Liu CF.

Neurobiol Aging · 2018-07-04

DOI: 10.1016/j.neurobiolaging.2018.06.036PMID: 30049590

İdiopatik Parkinson hastalığında LRRK2 aktivasyonu.

LRRK2 activation in idiopathic Parkinson's disease.

Di Maio R, Hoffman EK, Rocha EM, Keeney MT, Sanders LH, De Miranda BR, Zharikov A, Van Laar A, Stepan AF, Lanz TA, Kofler JK, Burton EA, Alessi DR, Hastings TG, Greenamyre JT.

Sci Transl Med · 2018-07-01

DOI: 10.1126/scitranslmed.aar5429PMID: 30045977

Parkinson Hastalığına Bağlı Proteinin Enzimatik Çekirdeği LRRK2 Yaşlanma Mayasında Mitokondriyal Biyogenezi İmpairs.

The Enzymatic Core of the Parkinson's Disease-Associated Protein LRRK2 Impairs Mitochondrial Biogenesis in Aging Yeast.

Aufschnaiter A, Kohler V, Walter C, Tosal-Castano S, Habernig L, Wolinski H, Keller W, Vögtle FN, Büttner S.

Front Mol Neurosci · 2018-06-21

DOI: 10.3389/fnmol.2018.00205PMID: 29977190

Dopamin D2 reseptör aktivasyonu, Parkinson hastalığının G2019S LRRK2 genetik modelinde striatal glutamaterjik iletimi güçlü bir şekilde inhibe eder.

Dopamine D2 receptor activation potently inhibits striatal glutamatergic transmission in a G2019S LRRK2 genetic model of Parkinson's disease.

Tozzi A, Durante V, Bastioli G, Mazzocchetti P, Novello S, Mechelli A, Morari M, Costa C, Mancini A, Di Filippo M, Calabresi P.

Neurobiol Dis · 2018-06-13

DOI: 10.1016/j.nbd.2018.06.008PMID: 29908325

Mitokondriyal ve otofajik rezervin tükenmesi LRRK2 ⁇ sup>G2019S ⁇ /sup> -Parkinson hastalığının gelişimine katkıda bulunabilir.

Exhaustion of mitochondrial and autophagic reserve may contribute to the development of LRRK2 ^G2019S -Parkinson's disease.

Juárez-Flores DL, González-Casacuberta I, Ezquerra M, Bañó M, Carmona-Pontaque F, Catalán-García M, Guitart-Mampel M, Rivero JJ, Tobias E, Milisenda JC, Tolosa E, Marti MJ, Fernández-Santiago R, Cardellach F, Morén C, Garrabou G.

J Transl Med · 2018-06-08

DOI: 10.1186/s12967-018-1526-3PMID: 29884186

Parkinson hastalığı VPS35[D620N] mutasyonu, fare ve insanda LRRK2 aracılı Rab protein fosforilasyonunu arttırır.

The Parkinson's disease VPS35[D620N] mutation enhances LRRK2-mediated Rab protein phosphorylation in mouse and human.

Mir R, Tonelli F, Lis P, Macartney T, Polinski NK, Martinez TN, Chou MY, Howden AJM, König T, Hotzy C, Milenkovic I, Brücke T, Zimprich A, Sammler E, Alessi DR.

Biochem J · 2018-06-06

DOI: 10.1042/bcj20180248PMID: 29743203

Crohn ve Parkinson hastalığı: LRRK2 köşede pusuda mı?

Crohn's and Parkinson disease: is LRRK2 lurking around the corner?

Derkinderen P, Neunlist M.

Nat Rev Gastroenterol Hepatol · 2018-06-01

DOI: 10.1038/s41575-018-0006-9PMID: 29666431

GBA ve LRRK2 İlgili Parkinson Hastalığı ve İlk Derece Etkilenmemiş Akrabalarının Serebral Görüntüleme İşaretleyicileri.

Cerebral Imaging Markers of GBA and LRRK2 Related Parkinson's Disease and Their First-Degree Unaffected Relatives.

Thaler A, Kliper E, Maidan I, Herman T, Rosenberg-Katz K, Bregman N, Gurevich T, Shiner T, Hausdorff JM, Orr-Urtreger A, Giladi N, Mirelman A.

Brain Topogr · 2018-05-30

DOI: 10.1007/s10548-018-0653-8PMID: 29846835

Parkinson hastalığında WAVE2 kompleks stabilizasyonu yoluyla LRRK2 tarafından miyeloid hücre fagositozunun düzenlenmesi değiştirilir.

Regulation of myeloid cell phagocytosis by LRRK2 via WAVE2 complex stabilization is altered in Parkinson's disease.

Kim KS, Marcogliese PC, Yang J, Callaghan SM, Resende V, Abdel-Messih E, Marras C, Visanji NP, Huang J, Schlossmacher MG, Trinkle-Mulcahy L, Slack RS, Lang AE, Canadian Lrrk2 in Inflammation Team (CLINT), Park DS.

Proc Natl Acad Sci U S A · 2018-05-14

DOI: 10.1073/pnas.1718946115PMID: 29760073

LRRK2 auxilin fosforilasyonu Parkinson hastalığı olan hastalardan dopaminerjik nöronlardaki sinaptik kusurları aracılık eder.

LRRK2 phosphorylation of auxilin mediates synaptic defects in dopaminergic neurons from patients with Parkinson's disease.

Nguyen M, Krainc D.

Proc Natl Acad Sci U S A · 2018-05-07

DOI: 10.1073/pnas.1717590115PMID: 29735704

LRRK2-associated Parkinson's disease patients have better stereopsis than idiopathic Parkinson disease.

Sun L, Chan P.

Clin Neurol Neurosurg · 2018-04-22

DOI: 10.1016/j.clineuro.2018.04.016PMID: 29705653