1.203 makale bulundu

Association of LRRK2 p.A419V with Parkinson's Disease in East Asians and analysis of age at onset.

Lim KS, Periñan MT, Chew EGY, Lee PS, Akçimen F, Lim JL, Koretsky MJ, Funayama M, Yoshino H, Hattori N, Kaiyrzhanov R, Houlden H, Isayan M, Tay YW, Toh TS, Lit LC, Khairul Anuar AN, Ding HX, Screven L, Ibrahim NM, Lin CH, Kim HJ, Lee JY, Chung SJ, Foo JN, Tan EK, Lim SY, Tan AH, Bandres-Ciga S, Ahmad-Annuar A, Global Parkinson’s Genetics Program (GP2).

NPJ Parkinsons Dis · 2026-02-02

DOI: 10.1038/s41531-026-01265-3PMID: 41629305

Extracellular Vesicle-Mediated Delivery of Constrained Peptides Disrupts the Pathogenic Interaction of LRRK2-FADD in Parkinson's Disease.

Vezikül-Medyalı Kısıtlı Peptitlerin Teslimi Parkinson Hastalığında LRRK2-FADD'nin Patojenik Etkileşimini Bozar.

Zheng Y, Jurgielewicz BJ, Helton LG, Rideout HJ, Kennedy EJ, Stice SL, Yao Y.

J Extracell Biol · 2026-01-31

DOI: 10.1002/jex2.70116PMID: 41625179

Multi-cohort, cross-species urinary proteomics reveals signatures of LRRK2 dysfunction in Parkinson's disease.

Çok kohortlu, çapraz tür idrar proteomikleri Parkinson hastalığında LRRK2 disfonksiyonunun izlerini ortaya koymaktadır.

Vu DT, Sibran W, Metousis A, Vandewynckel L, Eraslan B, Goveas L, Itang EC, Deldycke C, Figueroa-Garcia A, Lefèbvre R, Müller-Reif JB, Virreira Winter S, Chartier-Harlin MC, Taymans JM, Mann M, Karayel O.

Mol Syst Biol · 2026-01-29

DOI: 10.1038/s44320-026-00190-0PMID: 41611872

Analysis of α-synuclein seed amplification assay in carriers of <i>GBA1</i> and <i>LRRK2</i> pathogenic variants.

<i>GBA1</i> ve <i>LRRK2</i> patojenik varyantların taşıyıcılarında ⁇ -sinüklein tohum amplifikasyonu tahlilinin analizi.

Fraser KB, Mirelman A, Mabrouk OS, Omer N, Concha-Marambio L, Gurevich T, Bar-Shira A, Gana-Weisz M, Goldstein O, Orr-Urtreger A, Kestenbaum M, Cedarbaum JM, Dam T, Shirvan JC, Giladi N, Graham D, Alcalay RN, Thaler A.

J Parkinsons Dis · 2026-01-23

DOI: 10.1177/1877718x251392799PMID: 41574889

Genetic analysis of LRRK2 variants in Han Chinese patients with Parkinson's disease.

Deng X, Yan X, Song Z, Zheng W, Xu H, Yang Y, Wang J, Yuan L, Deng H.

PLoS One · 2026-01-08

DOI: 10.1371/journal.pone.0340448PMID: 41505438

No evidence for the LRRK2 p.L1795F variant in a Southern Italian cohort with Parkinson's disease.

Gagliardi M, Procopio R, Felicetti A, Quattrone A, Arabia G, Morelli M, Gambardella A, Annesi G, Quattrone A.

Gene · 2026-01-05

DOI: 10.1016/j.gene.2026.150001PMID: 41500415

Carriers of LRRK2 pathogenic variants show a milder, anatomically distinct brain signature of Parkinson's disease.

LRRK2 patojenik varyantlarının taşıyıcıları, Parkinson hastalığının daha hafif, anatomik olarak belirgin bir beyin imzasını göstermektedir.

Kopal J, Vo A, Tao Q, Simuni T, Chahine LM, Bzdok D, Dagher A.

Commun Med (Lond) · 2026-01-03

DOI: 10.1038/s43856-025-01330-7PMID: 41484352

Nuclear ASC speck formation in microglia is associated with inflammasome priming and is exacerbated in LRRK2-G2019S Parkinson's disease.

Ballotto L, Baratta T, Winterberg H, Dusanter C, Sambin S, Corvol JC, Iovino L, Bubacco L, Corti O, Greggio E, Novello S.

Neurobiol Dis · 2025-12-25

DOI: 10.1016/j.nbd.2025.107237PMID: 41455502

Parabacteroides goldsteinii mitigates parkinsonism in LRRK2 mutant mice by reducing neuroinflammation through Gut-Brain axis.

Lin JD, Li H, Hsu CL, Lin TL, Chuang HL, Lin HI, Ho EP, Chen YH, Liu CW, Chuang YT, Lung YY, Lien CJ, Chen HY, Wu WK, Wu MS, Lu CC, Lai HC, Lin CH.

J Adv Res · 2025-12-23

DOI: 10.1016/j.jare.2025.12.028PMID: 41448457

The LRRK2 P1446L mutation triggers dopaminergic neurodegeneration via DAPK1-mediated microglial neuroinflammation and neuronal apoptosis.

LRRK2 P1446L mutasyonu, DAPK1 aracılı mikroglial nöroinflamasyon ve nöronal apoptoz yoluyla dopaminerjik nörodejenerasyonu tetikler.

Ding L, Shu H, Chen M, Liang F, Gan T, Huang X, Liang X, Luo K, Qiu L, Huang W, Zhu X, Huang X, Zhang W, Xu P.

NPJ Parkinsons Dis · 2025-12-21

DOI: 10.1038/s41531-025-01234-2PMID: 41423638

One mutation, two phenotypes: cervical dystonia and parkinsonism with non-motor fluctuations in two sisters with LRRK2 G2019S variant.

Cartella SM, Battaglia A, Neri S, Malaspina M, Foti GM, Cartella G.

Neurol Sci · 2025-12-19

DOI: 10.1007/s10072-025-08633-6PMID: 41413317

GPNMB, LRRK2, and lysosome exocytosis in Parkinson's.

GPNMB, LRRK2 ve Parkinson'da lizozom ekzositoz.

Pfeffer SR.

Sci Adv · 2025-12-17

DOI: 10.1126/sciadv.aed8002PMID: 41406219