Bilimsel Makale Arama | NeuralCipher AI

Açık erişim

Interplay between lipid droplets and alpha-synuclein: implication in Parkinson's disease pathogenesis.

Idi W, Sheta R, Oueslati A.

Front Mol Neurosci · 2025-12-01

DOI: 10.3389/fnmol.2025.1681039PMID: 41404624

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Açık erişim

Dermal Alpha-Synuclein Aggregation in Seed Amplification Assays for Parkinson's Disease Subtype Differentiation.

Vieregge M, Kuzkina A, Janzen A, Oertel WH, Sommerauer M, Volkmann J, Doppler K.

Eur J Neurol · 2025-12-01

DOI: 10.1111/ene.70453PMID: 41316710

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Açık erişim

Alpha-Synuclein Neurobiology in Parkinson's Disease: A Comprehensive Review of Its Role, Mechanisms, and Therapeutic Perspectives.

Pitton Rissardo J, McGarry A, Shi Y, Fornari Caprara AL, Kannarkat GT.

Brain Sci · 2025-11-25

DOI: 10.3390/brainsci15121260PMID: 41440056

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Açık erişim

Synphilin-1 modulates alpha-synuclein assembly, release and uptake.

Lázaro DF, Amen T, Gerhardt E, Song C, Burns R, Kruse N, Santos PI, Milovanovic D, Höglinger G, Mollenhauer B, Luk KC, Lee VM, Outeiro TF.

NPJ Parkinsons Dis · 2025-11-20

DOI: 10.1038/s41531-025-01144-3PMID: 41266386

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Açık erişim

Inhibition of T cell infiltration and soluble TNF signaling is neuroprotective in the alpha-synuclein overexpressing mouse model of Parkinson's disease.

Tavira A, Basurco L, Abellanas MA, Ayerra L, Vidaurre C, Luquin E, Vales A, Gonzalez-Aseguinolaza G, Marrodan L, Alonso MM, Mengual E, Tansey MG, Hervás-Stubbs S, Aymerich MS.

NPJ Parkinsons Dis · 2025-11-11

DOI: 10.1038/s41531-025-01158-xPMID: 41219204

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Açık erişim

Organic electrolyte gated field effect transistor for detecting alpha synuclein longitudinally in Parkinsonism mouse model.

Johri S, Chan D, Massey RS, Knight D, DeRosa MC, Holahan MR, Prakash R.

NPJ Biosens · 2025-11-07

DOI: 10.1038/s44328-025-00057-8PMID: 41210581

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Kaynak kaydı

Early alpha-synuclein accumulation, oxidative stress and inflammation in the proximal colon of c-rel<sup>-/-</sup> mouse model of Parkinson's disease.

Parrella E, Gennari MM, Abate G, Pucci M, Schioppa T, Bosisio D, Tirelli E, Benarese M, Vegezzi G, Silletti MG, Fritzsch C, Uberti D, Pizzi M, Porrini V.

Neurobiol Dis · 2025-11-07

DOI: 10.1016/j.nbd.2025.107182PMID: 41207395

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Targeting the alpha-synuclein protein to treat Parkinson's disease using novel inhibitors identified using an integrated computational drug development approaches.

Siddiqui AJ, Jahan S, Saxena J, Sachidanandan M, Badraoui R, Adnan M.

In Silico Pharmacol · 2025-11-06

DOI: 10.1007/s40203-025-00477-4PMID: 41211461

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Açık erişim

Cognitive function correlates with gastric alpha-synuclein seeding activity in early Parkinson's disease.

Shin C, Im JP, Han JY, Jin B, Woo KA, Lee S, Jeon H, Joo JY, Chang HJ, Shin JH, Kim HJ, Kim JM, Choi YP, Jeon B.

NPJ Parkinsons Dis · 2025-11-04

DOI: 10.1038/s41531-025-01152-3PMID: 41188273

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Açık erişim

Evaluation of an antibody panel for alpha-synuclein detection in FFPE rectal biopsies in Parkinson's disease.

Schröder K, Kintrup C, Kulcsárová K, Heinzel S, Kluge A, Wedel T, Böttner M, Lucius R, Pendziwiat M, Schoch S, Ellrichmann M, Berg D, Schaeffer E, Cossais F.

IBRO Neurosci Rep · 2025-11-01

DOI: 10.1016/j.ibneur.2025.10.021PMID: 41280139

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Açık erişim

C-terminus-dependent detection of lysosomal alpha-synuclein in nigral Parkinson's disease human brain neurons.

Morella ML, Al Khayrat B, Moors TE, In't Veld L, Frigerio I, Udayar V, van der Gaag BL, van de Berg WDJ.

Mol Neurodegener · 2025-10-31

DOI: 10.1186/s13024-025-00884-3PMID: 41174681

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Açık erişim

Glycation of alpha-synuclein enhances aggregation and neuroinflammatory responses.

Vasili E, König A, Al-Azzani M, Bosbach C, Gatzemeier LM, Thom S, Chegão A, Vicente Miranda H, Steinem C, Erskine D, Outeiro TF.

NPJ Parkinsons Dis · 2025-10-23

DOI: 10.1038/s41531-025-01159-wPMID: 41131060

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715 makale bulundu

Interplay between lipid droplets and alpha-synuclein: implication in Parkinson's disease pathogenesis.

Dermal Alpha-Synuclein Aggregation in Seed Amplification Assays for Parkinson's Disease Subtype Differentiation.

Alpha-Synuclein Neurobiology in Parkinson's Disease: A Comprehensive Review of Its Role, Mechanisms, and Therapeutic Perspectives.

Synphilin-1 modulates alpha-synuclein assembly, release and uptake.

Inhibition of T cell infiltration and soluble TNF signaling is neuroprotective in the alpha-synuclein overexpressing mouse model of Parkinson's disease.

Organic electrolyte gated field effect transistor for detecting alpha synuclein longitudinally in Parkinsonism mouse model.

Early alpha-synuclein accumulation, oxidative stress and inflammation in the proximal colon of c-rel<sup>-/-</sup> mouse model of Parkinson's disease.

Targeting the alpha-synuclein protein to treat Parkinson's disease using novel inhibitors identified using an integrated computational drug development approaches.

Cognitive function correlates with gastric alpha-synuclein seeding activity in early Parkinson's disease.

Evaluation of an antibody panel for alpha-synuclein detection in FFPE rectal biopsies in Parkinson's disease.

C-terminus-dependent detection of lysosomal alpha-synuclein in nigral Parkinson's disease human brain neurons.

Glycation of alpha-synuclein enhances aggregation and neuroinflammatory responses.

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