1.210 makale bulundu

İnterferon gama, idiyopatik ve genetik Parkinson hastalığı monositlerinde LRRK2, GCase ve katepsin aktivitelerinde koordineli değişiklikleri uyarır.

Interferon gamma stimulates coordinated changes in LRRK2, GCase, and cathepsin activities in idiopathic and genetic Parkinson's disease monocytes.

Hughes LP, Wallings RL, Agin-Liebes J, Alcalay RN, Garrido A, Tansey MG, Dzamko N.

NPJ Parkinsons Dis · 2025-11-26

DOI: 10.1038/s41531-025-01185-8PMID: 41298592

Koruyucu mu Patojenik mi? Kinaz aktivitesi ve G2019S LRRK2-Associated Parkinson hastalığının nörogelişimsel kökenleri.

Protective or Pathogenic? Kinase activity and the neurodevelopmental origins of G2019S LRRK2-Associated Parkinson's disease.

Gatto EM, Espay AJ, Espindola M, Da Prat G, Kauffman MA.

Parkinsonism Relat Disord · 2025-11-25

DOI: 10.1016/j.parkreldis.2025.108133PMID: 41344986

Decision tree-based approach to robust Parkinson's disease subtyping using clinical data of the Michael J. Fox Foundation LRRK2 cross-sectional study.

Roy S, Krähe S, Marschollek M, Frieling H, Ganguly N, Wolff D.

Front Artif Intell · 2025-11-21

DOI: 10.3389/frai.2025.1668206PMID: 41356666

Parkinson'a Bağlı LRRK2 ve GBA1 Mutasyonları Pseudomonas aeruginosa'ya Periferal Bağışıklık Tepkisini Modüle eder.

Parkinson's-Linked LRRK2 and GBA1 Mutations Modulate the Peripheral Immune Response to Pseudomonas aeruginosa.

Mark JR, Staley HA, Titus AM, Agin-Liebes J, Garrido A, Hughes L, Dzamko N, Wallings RL, Tansey MG.

Mov Disord · 2025-11-19

DOI: 10.1002/mds.70123PMID: 41257354

LRRK2 p.G2385R ve p.R1628P çok ırklı bir Asya Parkinson kohortunda varyantlar: epidemiyoloji ve klinik içgörüler.

LRRK2 p.G2385R and p.R1628P variants in a multi-ethnic Asian Parkinson's Cohort: epidemiology and clinical insights.

Goh JW, Lim JL, Toh TS, Ong RY, Yong QH, Lew CCY, Hor JW, Tay YW, Zulkefli J, Khairul Anuar AN, Ding HX, Schee JP, Beh YY, Ibrahim KA, Mawardi AS, Lim TT, Looi I, Chia YK, Ooi JCE, Law WC, Wong SC, Lau YH, Teh PC, Ong TL, Cheah WK, Sammler E, Padmanabhan S, Lit LC, Tan EK, Ahmad-Annuar A, Lim SY, Tan AH.

NPJ Parkinsons Dis · 2025-11-18

DOI: 10.1038/s41531-025-01166-xPMID: 41253790

Dysfunctional Alternative Polyadenylation Modifies the Penetrance of LRRK2 Variants in Parkinson's Disease.

Yang S, Zhu Y, Yu P, Huang Y, Wang Z, Wang Y, Zhou Q, Zhang Y, Li B, Zhao G, Guo J, Xia K, Tang B, Li J.

Mov Disord · 2025-11-15

DOI: 10.1002/mds.70119PMID: 41239858

G2019S LRRK2 mutasyonu, Parkinson hastalığı modellerinde farklı yollar aracılığıyla ⁇ -sinüklein ve tau nöropatolojisini şiddetlendirir.

The G2019S LRRK2 mutation exacerbates α-synuclein and tau neuropathology through divergent pathways in Parkinson's disease models.

Tsafaras G, Cabezudo D, Wetzels L, Tsakogias I, Abey A, Bentea E, Sanchiz-Calvo M, Van den Haute C, Wade-Martins R, Baekelandt V.

Acta Neuropathol · 2025-11-11

DOI: 10.1007/s00401-025-02956-6PMID: 41217513

LRRK2 ve kırılgan sinaps: Parkinson hastalığına moleküler bir prelüd?

LRRK2 and the fragile synapse: a molecular prelude to Parkinson's disease?

Masotti B, Tombesi G, Parisiadou L, Greggio E.

Biochem J · 2025-10-28

DOI: 10.1042/bcj20253351PMID: 41148193

Parkinson hastalığı ile ilişkili LRRK2-G2019S varyantı, serin metabolizmasını kısıtlayarak mikroglial inflamasyona ve dopaminerjik nöron dejenerasyonuna yol açar.

The Parkinson's disease-associated LRRK2-G2019S variant restricts serine metabolism, leading to microglial inflammation and dopaminergic neuron degeneration.

Kurniawan H, Nickels SL, Zagare A, Zuccoli E, Rosety I, Gomez-Giro G, Glaab E, Schwamborn JC.

J Neuroinflammation · 2025-10-27

DOI: 10.1186/s12974-025-03577-2PMID: 41146185

Parkinson Hastalığı ve Enflamasyonu için LRRK2 Degraderler: Nörodejenerasyon için Tau ve ⁇ Synüklein Degraders.

LRRK2 Degraders for Parkinson's Disease and Inflammation: Tau and α‑Synuclein Degraders for Neurodegeneration.

Renner AC, Kargbo RB.

ACS Med Chem Lett · 2025-10-10

DOI: 10.1021/acsmedchemlett.5c00594PMID: 41257015

Association between <i>LRRK2</i> gene polymorphisms and Parkinson's disease progression in a Chinese Han population.

Zhang Z, Geng L, Gao J, She R, Ge Z, Liu J, He Q, Fu B, Liu W.

Front Genet · 2025-09-25

DOI: 10.3389/fgene.2025.1662348PMID: 41070227

Parkinson ve Alzheimer Hastalığı Hücresel Modelinde LRRK2-Ortamlı Nöroinflamasyon-İndüklenmiş Nöronal Disfonksiyonlar.

LRRK2-Mediated Neuroinflammation-Induced Neuronal Dysfunctions in a Parkinson's and Alzheimer's Disease Cellular Model.

Mutti V, Carini G, Marizzoni M, Filippini A, Bono F, Fiorentini C, Saleri S, De Cillis F, Cattaneo A, Gennarelli M, Martini P, Russo I.

Biomolecules · 2025-09-16

DOI: 10.3390/biom15091322PMID: 41008629