1.278 makale bulundu

Corrigendum to "Pyridoxal Phosphate inhibits alpha-synuclein-induced ferroptosis by activating GOT1 to enhance the methionine salvage pathway in Parkinson's Disease" [Experimental Neurology (2025) 115411].

Min X, Du Z, Wei J, Yuan Z, She Y, Jin X, Su Z, Mao H, Cai J, Zhu Z, He X.

Exp Neurol · 2025-08-20

DOI: 10.1016/j.expneurol.2025.115429PMID: 40841291

Glutamatergic synaptic resilience to overexpressed human alpha-synuclein.

Santos PI, García-Plaza IH, Shaib A, Rhee JS, Chouaib AA, Brose N, Rizzoli SO, Daniel J, Outeiro TF.

NPJ Parkinsons Dis · 2025-08-12

DOI: 10.1038/s41531-025-01085-xPMID: 40796780

Alpha-synuclein inclusions reduced by PIKfyve inhibition in Parkinson disease cell models.

Lucas-Del-Pozo S, Uras G, Fierli F, Lentini V, Koletsi S, Lazaro-Hernandez C, Chau KY, Hughes DA, Schapira AHV.

Neurobiol Dis · 2025-08-12

DOI: 10.1016/j.nbd.2025.107053PMID: 40812540

Expression of human A53T alpha-synuclein without endogenous rat alpha-synuclein fails to elicit Parkinson's disease-related phenotypes in a novel humanized rat model.

Polinski NK, Puoliväli J, Rauhala L, Stenius TK, Bragge T, Parkkari T, Penttinen AM, Chen Y, Mabrouk OS, Glajch KE, Hirst WD, Perkinton M, Martinez TN, Frasier MA.

PLoS One · 2025-08-08

DOI: 10.1371/journal.pone.0329823PMID: 40779487

Hope vs. Hype I: It is time to redefine and rename Parkinson disease based on alpha-synuclein.

Poston KL, Piccinin CC, Mestre TA.

Parkinsonism Relat Disord · 2025-08-06

DOI: 10.1016/j.parkreldis.2025.107983PMID: 40830017

Elevated plasma levels of alpha-synuclein are dispensable for Parkinson's disease pathology.

Jeong JY, Kim N, Li Y, Kim DJ, Kim HK, Oh WJ.

NPJ Parkinsons Dis · 2025-08-04

DOI: 10.1038/s41531-025-01091-zPMID: 40759658

Pyridoxal phosphate inhibits alpha-synuclein-induced ferroptosis by activating GOT1 to enhance the methionine salvage pathway in Parkinson's disease.

Min X, Du Z, Wei J, Yuan Z, She Y, Jin X, Su Z, Mao H, Cai J, Zhu Z, He X.

Exp Neurol · 2025-08-02

DOI: 10.1016/j.expneurol.2025.115411PMID: 40752725

Oligomeric alpha-synuclein causes early synaptic dysfunction of the corticostriatal pathway associated with non-motor symptoms.

Oligomerik alfa-sinüklein, motor olmayan semptomlarla ilişkili kortikostriyal yolun erken sinaptik disfonksiyonuna neden olur.

Bellingacci L, Sciaccaluga M, Megaro A, Cardinale A, Canonichesi J, De Carluccio M, Mastrantonio R, Costa C, Di Filippo M, Usiello A, Viscomi MT, Calabresi P, Tozzi A.

NPJ Parkinsons Dis · 2025-07-29

DOI: 10.1038/s41531-025-01075-zPMID: 40730592

Oleuropein Aglycone, an Olive Polyphenol, Influences Alpha-Synuclein Aggregation and Exerts Neuroprotective Effects in Different Parkinson's Disease Models.

Basellini MJ, Granadino-Roldán JM, Torres-Ortega PV, Simmini G, Rubio-Martinez J, Marin S, Cappelletti G, Cascante M, Cañuelo A.

Mol Neurobiol · 2025-07-24

DOI: 10.1007/s12035-025-05208-6PMID: 40702289

Neuromodulation influences T lymphocyte calcium signaling and alpha synuclein clearance: implications for Parkinson's disease.

Ross A, Prowse N, Zhang H, Hayley S, Sun H.

Front Cell Neurosci · 2025-07-18

DOI: 10.3389/fncel.2025.1627305PMID: 40756016

Synaptic enrichment of pSer129 alpha-synuclein correlates with dopaminergic denervation in early-stage Parkinson's disease.

PSer129 alfa-sinükleinin sinaptik zenginleşmesi, Parkinson hastalığının erken evrelerinde dopaminerjik denervasyon ile ilişkilidir.

Frigerio I, Morella ML, Winkelaar AB, Vorgia DT, Brevé JJ, Boiten WA, van der Gaag BL, Calandri IL, Jonker AJ, Berendse HW, Mona D, Britschgi M, Jonkman LE, van de Berg WD.

Nat Commun · 2025-07-18

DOI: 10.1038/s41467-025-61052-1PMID: 40681493

Parkinson's paradox: alpha-synuclein's selective strike on SNc dopamine neurons over VTA.

Parkinson paradoksu: alfa-sinükleinin VTA üzerindeki SNC dopamin nöronlarına seçici saldırısı.

Phan L, Miller D, Gopinath A, Lin M, Miller EJ, Guenther D, Quintin S, Borg D, Hasanpour-Segherlou Z, Newman A, Sorrentino Z, Seibold J, Hoh B, Giasson B, Khoshbouei H.

NPJ Parkinsons Dis · 2025-07-11

DOI: 10.1038/s41531-025-01055-3PMID: 40646031