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Efficacy and Safety of Safinamide as an Adjunct to Levodopa for Motor Fluctuations in Parkinson's Disease: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Ahmed AAO, Ahmed OAO, Dishean AS, Gilbert C, Elkheir MMAS, Sota HA, Abdulaziz MAM, Mahmoud EYM, Ahmed RAO.

Parkinsons Dis · 2026-10-06

DOI: 10.1155/padi/9352886PMID: 42846716

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Combination therapy of levodopa with safinamide is more effective than with rasagiline and zonisamide in Asian Parkinson's disease patients with motor fluctuations: a systematic review and network meta-analysis of randomized controlled trials.

Wang Y, Wang XX, Yuan BJ, Li X, Zhang YL, Yang XH, Hou DL, Peng SJ, Li XJ, Feng Y, Zhou ZD, Tan EK, Wu YC.

J Neurol · 2026-06-14

DOI: 10.1007/s00415-026-13910-1PMID: 42289483

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Comparison of blood dopamine in Parkinson's patients treated with levodopa carbidopa entacapone vs levodopa benserazide: A randomized controlled trial.

Korucu O, Özdemir S, Türkeş GF, Savici V, Emektar E.

Medicine (Baltimore) · 2026-05-01

DOI: 10.1097/md.0000000000048895PMID: 42175483

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Efficacy of Levodopa/Benserazide Dispersible Tablets on "Delayed ON " to the First Morning Dose in Patients With Parkinson's Disease With Motor Fluctuations: A Multicenter, Randomized, Open-Label, Crossover Trial.

Chang HJ, Park J, Oh S, Shin C, Kim JW, Cho JW, Lee JY.

J Mov Disord · 2025-05-07

DOI: 10.14802/jmd.25031PMID: 40328429

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Comparative efficacy of Mucuna pruriens and conventional levodopa in Parkinson's disease: a randomized controlled trial on pharmacokinetics and clinical perspectives from Asia.

Boonmongkol T, Phokaewvarangkul O, Vimolmangkang S, Wattanavijitkul T, Komenkul V, Bhidayasiri R.

J Neural Transm (Vienna) · 2025-03-26

DOI: 10.1007/s00702-025-02914-2PMID: 40137945

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Mesdopetam for the Treatment of Levodopa Induced Dyskinesia in Parkinson's Disease: A Randomized Phase 2b Trial.

Antonini A, O'Suilleabhain P, Stocchi F, Landström J, Waters S, Sonesson C, Tedroff J.

Mov Disord Clin Pract · 2025-02-26

DOI: 10.1002/mdc3.70004PMID: 40008823

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Opicapone as adjunct to levodopa in treated Parkinson's disease without motor complications: A randomized clinical trial.

Ferreira JJ, Rascol O, Stocchi F, Antonini A, Moreira J, Castilla-Fernández G, Rocha JF, Holenz J, Poewe W, Epsilon Study investigators.

Eur J Neurol · 2025-01-01

DOI: 10.1111/ene.16420PMID: 39790009

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Bromocriptine Versus Levodopa and other treatments in Parkinson's Disease: an updated Meta-analysis Involving more than 4000 patients across 12 randomized clinical trials.

Afshar M, Sane N, Moradi Y.

Acta Neurol Belg · 2024-12-24

DOI: 10.1007/s13760-024-02711-wPMID: 39718740

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Efficacy and safety of Tianqi Pingchan Granule, a compound Chinese herbal medicine, for levodopa-induced dyskinesia in Parkinson's disease: A randomized double-blind placebo-controlled trial.

Zhang Y, Zhu XB, Zhao Y, Cui GY, Li WT, Yuan CX, Huang JP, Wan Y, Wu N, Song L, Zhao JH, Liang Y, Xu CY, Liu MJ, Gao C, Chen XX, Liu ZG.

J Integr Med · 2024-07-09

DOI: 10.1016/j.joim.2024.07.002PMID: 39060125

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Oxycodone or Higher Dose of Levodopa for the Treatment of Parkinsonian Central Pain: OXYDOPA Trial.

Brefel-Courbon C, Harroch E, Marques A, Devos D, Thalamas C, Rousseau V, Ory-Magne F, Fabbri M, Maltête D, Rouaud T, Drapier S, Tir M, Thobois S, Salhi H, Corvol JC, Castelnovo G, Lagha-Boukbiza O, Fluchère F, Frismand S, Ansquer S, Sommet A, Rascol O.

Mov Disord · 2024-06-08

DOI: 10.1002/mds.29878PMID: 38850081

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Safety and efficacy of continuous subcutaneous levodopa-carbidopa infusion (ND0612) for Parkinson's disease with motor fluctuations (BouNDless): a phase 3, randomised, double-blind, double-dummy, multicentre trial.

Espay AJ, Stocchi F, Pahwa R, Albanese A, Ellenbogen A, Ferreira JJ, Giladi N, Gurevich T, Hassin-Baer S, Hernandez-Vara J, Isaacson SH, Kieburtz K, LeWitt PA, Lopez-Manzanares L, Olanow CW, Poewe W, Sarva H, Yardeni T, Adar L, Salin L, Lopes N, Sasson N, Case R, Rascol O, BouNDless Study Group.

Lancet Neurol · 2024-03-15

DOI: 10.1016/s1474-4422(24)00052-8PMID: 38499015

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IPX203 vs Immediate-Release Carbidopa-Levodopa for the Treatment of Motor Fluctuations in Parkinson Disease: The RISE-PD Randomized Clinical Trial.

Hauser RA, Espay AJ, Ellenbogen AL, Fernandez HH, Isaacson SH, LeWitt PA, Ondo WG, Pahwa R, Schwarz J, Stocchi F, Zeitlin L, Banisadr G, Fisher S, Visser H, D'Souza R.

JAMA Neurol · 2023-10-01

DOI: 10.1001/jamaneurol.2023.2679PMID: 37578800

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Kayıtlar bilimsel kaynaklardan alınır. Bibliyografik kayıt sayısı, Türkçe çeviri veya editoryal onay sayısı değildir.

55 makale bulundu

Efficacy and Safety of Safinamide as an Adjunct to Levodopa for Motor Fluctuations in Parkinson's Disease: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Combination therapy of levodopa with safinamide is more effective than with rasagiline and zonisamide in Asian Parkinson's disease patients with motor fluctuations: a systematic review and network meta-analysis of randomized controlled trials.

Comparison of blood dopamine in Parkinson's patients treated with levodopa carbidopa entacapone vs levodopa benserazide: A randomized controlled trial.

Efficacy of Levodopa/Benserazide Dispersible Tablets on "Delayed ON " to the First Morning Dose in Patients With Parkinson's Disease With Motor Fluctuations: A Multicenter, Randomized, Open-Label, Crossover Trial.

Comparative efficacy of Mucuna pruriens and conventional levodopa in Parkinson's disease: a randomized controlled trial on pharmacokinetics and clinical perspectives from Asia.

Mesdopetam for the Treatment of Levodopa Induced Dyskinesia in Parkinson's Disease: A Randomized Phase 2b Trial.

Opicapone as adjunct to levodopa in treated Parkinson's disease without motor complications: A randomized clinical trial.

Bromocriptine Versus Levodopa and other treatments in Parkinson's Disease: an updated Meta-analysis Involving more than 4000 patients across 12 randomized clinical trials.

Efficacy and safety of Tianqi Pingchan Granule, a compound Chinese herbal medicine, for levodopa-induced dyskinesia in Parkinson's disease: A randomized double-blind placebo-controlled trial.

Oxycodone or Higher Dose of Levodopa for the Treatment of Parkinsonian Central Pain: OXYDOPA Trial.

Safety and efficacy of continuous subcutaneous levodopa-carbidopa infusion (ND0612) for Parkinson's disease with motor fluctuations (BouNDless): a phase 3, randomised, double-blind, double-dummy, multicentre trial.

IPX203 vs Immediate-Release Carbidopa-Levodopa for the Treatment of Motor Fluctuations in Parkinson Disease: The RISE-PD Randomized Clinical Trial.

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