Yeni bir sentetik bileşik PHID (8-Phenyl-6a, 7, 8, 9, 9a, 10-heksahidro-6H-izoindolo [5, 6-g] quinoxaline-7, 9-dione), SH-SY5Y hücrelerini reaktif oksijen türlerinin neslinin ve JNK sinyallemesinin inhibisyonu yoluyla MPP(+) kaynaklı sitotoksisiteye karşı korur.

A novel synthetic compound PHID (8-Phenyl-6a, 7, 8, 9, 9a, 10-hexahydro-6H-isoindolo [5, 6-g] quinoxaline-7, 9-dione) protects SH-SY5Y cells against MPP(+)-induced cytotoxicity through inhibition of reactive oxygen species generation and JNK signaling.

Kim IS, Koppula S, Kim BW, Song MD, Jung JY, Lee G, Lee HS, Choi DK.

Eur J Pharmacol · 2010-10-12

DOI: 10.1016/j.ejphar.2010.09.063PMID: 20946892