Bir dizi N-4- (2,5-dioksopyrolidin-1-yl) fenilopolinamidlerin (VU0400195, ML182) keşfi, sentezi ve yapı-aktivite ilişkisi gelişimi: antiparkinsonian hayvan modelinde oral etkililiği olan metabotropik glutamat reseptör 4 (mGlu4)'ün yeni bir pozitif allosterik modülatörün karakterizasyonu.

Discovery, synthesis, and structure-activity relationship development of a series of N-4-(2,5-dioxopyrrolidin-1-yl)phenylpicolinamides (VU0400195, ML182): characterization of a novel positive allosteric modulator of the metabotropic glutamate receptor 4 (mGlu(4)) with oral efficacy in an antiparkinsonian animal model.

Jones CK, Engers DW, Thompson AD, Field JR, Blobaum AL, Lindsley SR, Zhou Y, Gogliotti RD, Jadhav S, Zamorano R, Bogenpohl J, Smith Y, Morrison R, Daniels JS, Weaver CD, Conn PJ, Lindsley CW, Niswender CM, Hopkins CR.

J Med Chem · 2011-10-19

DOI: 10.1021/jm200956qPMID: 21966889