Simvastatin, maymunlarda levodopa kaynaklı diskineziyi azaltır, ancak Parkinson hastalığı hastalarında levodopa kaynaklı diskineziye karşı simvastatinin randomize, plasebo kontrollü, çoklu çaprazlamalı ("n-of-1") keşif denemesinde değildir.

Simvastatin decreases levodopa-induced dyskinesia in monkeys, but not in a randomized, placebo-controlled, multiple cross-over ("n-of-1") exploratory trial of simvastatin against levodopa-induced dyskinesia in Parkinson's disease patients.

Tison F, Nègre-Pagès L, Meissner WG, Dupouy S, Li Q, Thiolat ML, Thiollier T, Galitzky M, Ory-Magne F, Milhet A, Marquine L, Spampinato U, Rascol O, Bezard E.

Parkinsonism Relat Disord · 2012-12-31

DOI: 10.1016/j.parkreldis.2012.12.003PMID: 23283428