Erken başlangıçlı Parkinson hastalığı: Klinik-patolojik bir çalışma.

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BackgroundSeveral studies have compared early-onset Parkinson disease (EOPD) and late-onset Parkinson disease (LOPD) but most are not based on autopsy confirmed cases.MethodsWe compared clinical and pharmacological profiles, time to reach irreversible Hoehn and Yahr (H&Y) Stage 3 and levodopa motor complications in autopsy confirmed EOPD and LOPD cases.ResultsAt first clinic visit EOPD cases were younger but had longer disease duration and they died at a younger age (all pConclusionsOur observations indicate that progression of PD is slower in EOPD and suggest that the pre-clinical interval in this group is longer. These findings can be used for case selection for drug trials and studies of the pathogenesis of PD.

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