Tirozin Hidroksilaz, Veziküler Monoamin Transporter ve Dopamin Transporter mRNA İfadesi, Pedunculopontin Nörotoksik Lezyonlu Farelerin Nigrostriyal Dokusunda.

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BackgroundThe degeneration of the pedunculopontine nucleus (PPN) precedes the degeneration of the nigral cells in the pre-symptomatic stages of Parkinson's disease (PD). Although the literature recognizes that a lesion of the PPN increases the vulnerability of dopaminergic cells, it is unknown if this risk is associated with the loss of capability of handling the dopaminergic function.MethodsIn this paper, the effects of a unilateral neurotoxic lesion of the PPN in tyrosine hydroxylase (TH), vesicular monoamine transporter 2 (VMAT2) and dopamine transporter (DAT) mRNA expression in nigrostriatal tissue were evaluated. Three experimental groups were organized: non-treated rats, NMDA-lesioned rats and Sham-operated rats.ResultsSeven days after the PPN lesion, in nigral tissue, TH mRNA expression was higher in comparison with control groups (p p p ConclusionsFindings suggest that the PPN lesion modifies the mRNA expression of the proteins associated with dopaminergic homeostasis at nigrostriatal level. It could represent vulnerability signals for nigral dopaminergic cells and further increase the risk of degeneration of these cells.

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