Monoamin nöronlara verilen anti- ⁇ -sinüklein ASO, Parkinson hastalığı benzeri fare modelinde ve maymunlarda ⁇ -sinüklein birikimini önler.

Anti-α-synuclein ASO delivered to monoamine neurons prevents α-synuclein accumulation in a Parkinson's disease-like mouse model and in monkeys.

Alarcón-Arís D, Pavia-Collado R, Miquel-Rio L, Coppola-Segovia V, Ferrés-Coy A, Ruiz-Bronchal E, Galofré M, Paz V, Campa L, Revilla R, Montefeltro A, Kordower JH, Vila M, Artigas F, Bortolozzi A.

EBioMedicine · 2020-08-15

DOI: 10.1016/j.ebiom.2020.102944PMID: 32810825