Yükseltilmiş Serum Serüloplazmin Seviyeleri Parkinson Hastalığı Olan İnsanlarda Daha Yüksek İmpulsitivite ile İlişkilidir.

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BackgroundHeightened impulsivity has been reported in a subset of people with Parkinson's disease (PwP) and is considered a risk factor for the development of impulse control disorders (ICDs). However, at present, there are no recognised biochemical markers of heightened impulsivity.ObjectivesTo determine if ceruloplasmin, a serum marker involved in the regulation of iron and copper homeostasis, is associated with trait impulsivity in PwP.MethodsThe study measured serum ceruloplasmin and impulsivity using the Barratt Impulsiveness Scale (BIS-11) in an Australian cohort of 214 PwP. Multivariate general linear models (GLMs) were used to identify whether higher serum ceruloplasmin levels (>75th percentile) were significantly predictive of BIS-11 scores.ResultsSerum ceruloplasmin was higher in females with PD (p p nd order nonplanning impulsivity and with the 1st order self-control and cognitive complexity impulsivity domains.ConclusionsHigher serum ceruloplasmin levels are independently associated with heightened nonplanning impulsivity in PwP. Thus, serum ceruloplasmin levels may have clinical utility as a marker for heightened impulsivity in PD.

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