⁇ i>Bifidobacterium longum ⁇ /i> BB536 ve ⁇ i>Lactobacillus rhamnosus ⁇ /i> HN001'in Parkinson Hastalığı Rotenone-İndüklenmiş Zebrafish Modelinde Lokomotor Aktivite ve Oksidatif Stres Üzerine Olası Rolü.

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BackgroundAs every organ within the body, the brain is also extremely susceptible to a plethora of noxious agents that change its chemistry. One component frequently found in current products against harmful species to crops is rotenone whose effect under prolonged exposure has been demonstrated to cause neurodegenerative disorders such as Parkinson's disease. The latest reports have indeed revealed that rotenone promotes Parkinson's in humans, but studies aiming to show congruent effects in zebrafish (Danio rerio) are lacking. Material and Methods. In this context, the aim of the present study was to demonstrate how chronic administration of rotenone for 3 weeks impairs the locomotor activity and sociability and induces oxidative stress in zebrafish.ResultsThere were no statistically significant differences following the analysis of their social interaction and locomotor tests (p > 0.05). However, several exceptions have been noted in the control, rotenone, and probiotics groups when we compared their locomotor activity during the pretreatment and treatment interval (p p > 0.05), relevant changes have been observed between the analyzed groups (p p p ConclusionsOur results suggest that rotenone can be successfully used to trigger Parkinson's disease-related symptomatology in zebrafish.

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