⁇ -Serine 129'daki sinüklein fosforilasyon, ilk protein birikiminden sonra ortaya çıkar ve tohumlanmış fibril oluşumunu ve toksisiteyi inhibe eder.

α-Synuclein phosphorylation at serine 129 occurs after initial protein deposition and inhibits seeded fibril formation and toxicity.

Ghanem SS, Majbour NK, Vaikath NN, Ardah MT, Ardah MT, Erskine D, Jensen NM, Fayyad M, Sudhakaran IP, Vasili E, Melachroinou K, Abdi IY, Poggiolini I, Santos P, Dorn A, Carloni P, Vekrellis K, Attems J, McKeith I, Outeiro TF, Jensen PH, El-Agnaf OMA.

Proc Natl Acad Sci U S A · 2022-03-30

DOI: 10.1073/pnas.2109617119PMID: 35353605