⁇ sup>18 ⁇ /sup>F-BCPP-EF ⁇ 2- ⁇ i>tert ⁇ /i>-Butil-4-Chloro-5- ⁇ 6-[2-(2[ ⁇ sup>18 ⁇ /sup>F]floroethoksi]-Ethoxy]-Pyrridin-3-ilmethoxy ⁇ -2 ⁇ i>-Pyrzinda-3-Pyrzione

Araştırma özeti

Aşağıdaki metin kaynak makalenin lisansı doğrulanmış orijinal özetidir. cc by

Mitochondrial complex I (MC-I) is an essential component of brain bioenergetics and can be quantified and studied using positron emission tomography (PET). A specific high affinity 18F radiotracer for MC-I enables monitoring of neurodegenerative disease progression and pathology via PET imaging. To facilitate clinical research studies tracking MC-I activity in Parkinson's disease and other neurodegenerative diseases, a fully automated synthesis of the recently described 2-tert-butyl-4-chloro-5-{6-[2-(2[18F]fluoroethoxy)-ethoxy]-pyridin-3-ylmethoxy}-2H-pyridazin-3-one ([18F] BCPP-EF, [ 18 F]1) was developed. We report the first automated synthesis [18F]BCPP-EF using a green radiochemistry approach. The radiotracer was synthesized with good radiochemical yield, excellent radiochemical purity, and high molar activity.

İlgili konular