Yürüyüşün dondurulması Parkinson hastalığında bilişsel düşüş için bir risk faktörüdür.

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BackgroundsFreezing of gait (FOG) and cognitive impairment are serious symptoms of Parkinson's disease (PD). Understanding the association between FOG and cognition may help formulate specific interventions for PD individuals.ObjectivesWe aimed to investigate the associations of cognitive impairment in different domains with FOG status using multiple neuropsychological tests.MethodsTwo cohorts including 691 and 104 participants were recruited from Parkinson's progression markers initiative (PPMI) and central China, respectively. All participants underwent FOG assessment and neuropsychological tests, and 595 individuals from PPMI and 51 from central China were enrolled for longitudinal observation. Cross-sectional and longitudinal associations between cognition and FOG status were evaluated using multivariable-adjusted models.ResultsWorse cognitive performances were observed in patients with FOG compared to those without FOG in both cohorts (β = - 0.020, p ConclusionsFOG is a risk factor for cognitive decline in PD, which emphasizes the need for early detection and monitoring of cognitive changes and interventions on cognitive impairments in PD patients with FOG.

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