Parkinson hastalarında beyin kaynaklı nörotrofik faktörün rolü üzerine bir meta-analiz.

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BackgroundBrain-derived neurotrophic factor (BDNF) is essential for the development of dopaminergic neurons in the substantia nigra.ObjectivesTo investigate the level of BDNF among Parkinson's disease (PD) subjects and the influence of depression on BDNF levels.Material and methodsA total of 1920 subjects were included in the analysis; of these, 1034 had PD and 886 were healthy controls. A thorough literature search up to May 2022 was conducted. The mean difference (MD) of BDNF levels and 95% confidence intervals (95% CIs) were calculated with random or fixed effects models.ResultsCompared to healthy controls, levels of BDNF were significantly lower in patients with PD (MD = -1.60, 95% CI (-2.49, -0.70), p ConclusionCompared with healthy controls, BDNF levels were significantly lower in the subjects with PD combined with depression, and PD without depression. However, there was no discernible difference in BDNF levels between subjects with PD with depression compared to those with PD without depression.

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