Beta Burst Karakteristikleri ve Sensorimotor Kortikal-Subtalamik Nükleus Devresi içindeki Kavrama Dinamik olarak Parkinson Hastalığında Bradykinezi ile ilişkilidir.

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BackgroundBursts of exaggerated subthalamic nucleus (STN) beta activity are believed to contribute to clinical impairments in Parkinson's disease (PD). No previous studies have explored burst characteristics and coupling across the sensorimotor cortical-STN circuit and determined their relationship to dynamic measurements of bradykinesia.ObjectiveWe sought to (1) establish the characteristics of sensorimotor cortical and STN bursts during naturalistic behaviors, (2) determine the predictability of STN bursts from motor cortical recordings, and (3) relate burst features to continuous measurements of bradykinesia using wearable sensors.MethodsWe analyzed 1046 h of wirelessly streamed bilateral sensorimotor cortical and STN recordings from 5 PD patients with concurrent measurements of bradykinesia.ResultsSTN bursts were longer than cortical bursts and had shorter inter-burst intervals. Long bursts (>200 ms) in both structures displayed temporal overlap (>30%), with cortical bursts tending to lead STN burst onset by 8 ms. Worsening bradykinesia was linked to increased cortical burst rates and durations, whereas STN burst properties had the opposite effect.ConclusionCortical beta bursts tend to precede STN beta bursts with short delays and their occurrence relates to worsening bradykinesia in naturalistic settings. © 2025 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.

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