Uzun Vadeli Faydası Olmayan POLR3A-Bağımlı Serebellar Sendromu Olan Bir Hastada Tremor için VIM'nin Derin Beyin Uyarımı.

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BackgroundDeep brain stimulation is an approved therapy for essential tremor and Parkinson's disease. In addition, VIM-DBS is used off-label for the treatment of tremor syndromes with a different etiology.Case reportWe present the case of a woman with a drug-refractory action tremor due to rare compound heterozygous POLR3A mutations. Her treatment with VIM DBS did not lead to a sustained improvement of symptoms.DiscussionTremor due to POLR3A-related cerebellar syndromes may not be responsive to VIM DBS. The networks contributing to cerebellar tremor should be better investigated in terms of where neuromodulatory therapy might be more effective.

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