Aminerjik GPCR Ligandları Olarak Arylpiperazines'in Yapısal Yönleri.

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Arylpiperazines are considered a "privileged scaffold" in medical chemistry due to their versatility and modular structure, enabling modifications towards diverse molecular targets with desired potency, selectivity, and pharmacokinetic properties. In particular, arylpiperazines are aminergic G protein-coupled receptor (GPCR) ligands and neurotransmitter transporter inhibitors, making this group of compounds attractive in central nervous system (CNS) drug discovery for treating schizophrenia, depression, sleep disorders, and Parkinson's disease (PD). Furthermore, arylpiperazines may possess anticancer properties and can modulate some molecular targets involved in this disease. This review focuses on the structural aspects of arylpiperazines as aminergic GPCR ligands. The review centers on biologically active arylpiperazines with known X-ray structures, providing a detailed discussion of the conformations in the solid state. Next, their interactions with the aminergic GPCRs, based on experimental and molecular modelling studies, are addressed, making this review a comprehensive resource for medicinal and structural chemists working on arylpiperazines.

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