Parkinson hastalığı ve tip 2 diabetes mellitus hastalarında motor ve motor olmayan semptomlarla periferik enflamatuar sitokinler birliği.

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ObjectiveThis pilot study aims to investigate the association between peripheral inflammatory cytokines and motor and non-motor symptoms in patients with both Parkinson's disease (PD) and type 2 diabetes mellitus (T2DM) and the underlying mechanisms.MethodsSixty patients with PD were divided into two groups depending on whether they also had T2DM, resulting in a PD group (21 cases) and a PD-T2DM group (39 cases). Thirty healthy volunteers from the physical examination centre were enrolled as the control group. Peripheral blood was collected from all patients.ResultsPatients with PD-T2DM had higher Movement Disorders Society Unified Parkinson's Disease Rating Scale (MDS-UPDRS) III scores; total MDS-UPDRS scores; Parkinson's Disease Questionnaire-39 (PDQ-39) scores; and interleukin (IL)-6, IL-1β, tumour necrosis factor alpha (TNF-α) and IL-4 levels than patients with PD (p r = 0.337), Non-Motor Symptom Scale (r = 0.354), Hamilton Depression Scale (r = 0.420) and PDQ-39 (r = 0.423) scores (p β = -0.497, p = 0.018), TNF-α correlated with PD duration (β = 0.689, p β = 0.462, p = 0.002) in patients with PD-T2DM. Adjusted models explained up to 52.3% of variance (adjusted R2). In the PD group, age-adjusted correlations confirmed IL-4 was associated with UPDRS II (r = 0.321, p = 0.047) and PDQ-39 (r = 0.418, p = 0.009), and interferon gamma (IFN-γ) was associated with Scales for Outcomes in Parkinson's Disease-Autonomic Questionnaire (SCOPA-AUT; r = -0.564, p = 0.001). Negative correlations were identified between IL-6 and UPDRS III scores (r = -0.497) and IFN-γ and SCOPA-AUT scores (r = -0.588; p ConclusionThese pilot findings suggest peripheral inflammatory cytokines can be considered biomarkers in patients with PD-T2DM. The underlying mechanism by which T2DM worsens the motor and non-motor symptoms of PD may involve increased inflammation.

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