D vitamininin nöroprotektif rolleri: Bilişsel düşüşte mekanizmalar ve klinik uygulamalar arasındaki boşluğun köprülenmesi.

Araştırma özeti

Aşağıdaki metin kaynak makalenin lisansı doğrulanmış orijinal özetidir. cc by

Cognitive function is critical for overall health, with vitamin D's impact under extensive investigation. This review explores the association between vitamin D and cognitive health, its neuroprotective mechanisms, and the therapeutic potential of supplementation in cognitive decline. Observational studies link low vitamin D levels to increased cognitive deterioration risk, particularly in Alzheimer's disease, vascular dementia, Parkinson's disease, and schizophrenia. Clinical trial results on vitamin D supplementation's cognitive benefits are inconclusive. Vitamin D's neuroprotective effects are complex, influencing cognitive abilities by interacting with neuronal and glial cells, modulating immune responses, and regulating key molecular pathways. Challenges remain in clinical applications, including determining optimal vitamin D levels, effective supplementation forms and doses, and identifying responsive populations. The review advocates for robust clinical trials to address these gaps, facilitating informed use of vitamin D in cognitive health. Future research should focus on the optimal timing, duration, and target groups for supplementation to enhance cognitive outcomes and reduce risks.

İlgili konular