De novo Parkinson hastalığında bilişsel ilerleme ile renal fonksiyon birliği.

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BackgroundPeople with chronic kidney disease (CKD) who had decreased renal function were more likely to develop cognitive decline in contrast to the general population.ObjectiveWhether renal function parameters can effectively predict cognitive progress in Parkinson's disease is not yet clear.MethodsIn the present study, 612 de novo Parkinson's Disease (PD) patients from the Parkinson's Progression Markers Initiative (PPMI) database were recruited. To examine the associations between renal function parameters and cognition we utilized multiple linear regression models and mixed-effects models. Cox regression was used to investigate whether the renal function parameters were the risk factors for developing dementia in PD participants.ResultsRegression analyses indicated that creatinine (Cr), blood urea nitrogen (BUN), Blood urea nitrogen / Creatinine ratio (BUN/Cr), and estimated glomerular filtration rate(eGFR) were strongly associated with cognitive score as indicated by global cognition (MoCA, β = 0.066, p = 0.015; β = -0.043, p = 0.025; β = -0.070, p ConclusionsOur findings revealed the relationship between renal function and cognition in PD patients, which indicated that renal function might play a role in cognitive progression in de novo Parkinson's.

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