Parkinson hastalığı olan hastalarda akselerometri kullanılarak klinik bradikinezi ölçümlerinin perioperatif niceliği.

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ObjectiveThe gold standard for assessing bradykinesia in Parkinson's disease (PD) is the Movement Disorder Society Unified PD Rating Scale (MDS-UPDRS), although it is inherently subjective and relies on experienced raters. Therefore, we translated MDS-UPDRS upper limb bradykinesia assessments into an objective scoring method with 3D-accelerometry.MethodsIn this study, 44 PD-patients and 44 healthy controls (sex and age matched) were included. Two raters assessed MDS-UPDRS criteria for bradykinesia, while accelerometric measurements were conducted at the index fingers. Measurements were performed in an off-medication state. The 3D-acceleration data produced quantitative measures, like frequency and amplitude of hand movement. The algorithm for calculating accelerometric scores was based on MDS-UPDRS criteria with thresholds from healthy controls. Agreement between MDS-UPDRS bradykinesia scores and accelerometric scores was estimated with Cohen's kappa-coefficient (κ).ResultsThe accelerometric scores showed moderate agreement (κ ≥ 0.548) with MDS-UPDRS ratings. The inter-rater agreement between the two MDS-UPDRS raters was moderate for all tests (κ ≥ 0.595). Accelerometric test-retest reliability was good to excellent (ICC ≥ 0.764, p ConclusionsThis study introduces an accelerometric algorithm to classify upper extremity bradykinesia according to MDS-UPDRS criteria, yielding high test-retest reliability.SignificanceGiven its consistency, this method could reduce MDS-UPDRS rater-dependency and improve objective monitoring of upper limb bradykinesia.

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