Thalamik metabolit Parkinson hastalığında subtalamik çekirdek derin beyin stimülasyonundan sonra değişir: bir keşif manyetik rezonans spektroskopisi çalışması.

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IntroductionThe mechanisms underlying the clinical effect of Deep Brain Stimulation (DBS) for Parkinson's disease (PD) remain debated. Proton magnetic resonance spectroscopy (1H-MRS) provides a biochemical non-invasive in vivo insight. This article aims to increase the understanding of advanced PD pathophysiology and DBS using MRS before and after surgery.MethodsEleven PD patients and seven healthy controls were included. Preoperatively and approximately 7 months postoperatively, single-voxel MRS using a PRESS sequence was performed on a 1.5 T (tesla) system. Voxels were placed bilaterally in the thalamus (14 × 13 × 13 mm3) and the lentiform nucleus (15 × 13 × 12 mm3). Metabolite concentrations of total N-acetylaspartate + N-acetyl-aspartyl-glutamate (tNA), total creatine + phosphocreatine (tCr), total choline + phosphocholine + glycerophosphocholine (tCho), and total glutamate and glutamine, which together constitute Glx were quantified. To assess treatment outcomes following surgery, medications were converted to levodopa equivalent doses (LED) using a standardized conversion formula, both pre- and post-DBS.ResultsA total of 11 patients, with a mean PD duration of 9.4 years, were implanted with bilateral implantation (22 leads). All patients self-reported relief of symptoms and significantly reduced their medication (p p = 0.02) and relative to preoperative concentrations within the patient group (p = 0.03). No furher resulting concentrations differed.ConclusionWe present novel metabolite observations obtained through MRS in this exploratory study. Thalamic tNA concentrations in PD patients were comparable to those of healthy controls prior to surgery, but were significantly reduced following DBS implantation targeting the STN. These findings suggests the presence of a metabolite thalamic effect associated with DBS treatment.

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