Parkinson hastalığı semptomlarını hafifletmek ve hemşirelik bakımını iyileştirmek için nöroprotektif, çevre dostu demir oksit nanopartikülleri.

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BackgroundParkinson's disease (PD) involves motor impairment and neurochemical changes, necessitating neuroprotective agents to enhance nursing care outcomes.MethodsIron oxide nanoparticles (IONPs) were biosynthesized via green chemistry and characterized by TEM, UV-Vis, photoluminescence, XRD, and VSM. Antioxidant activity used DPPH assay; biocompatibility involved MTT and hemolysis assays. Efficacy was tested in an MPTP-induced mouse model of PD, assessing motor function, antioxidant capacity, and dopaminergic neuron protection.ResultsIONPs exhibited spherical morphology (39.0 ± 11.3 nm), zeta potential of -13 mV, and saturation magnetization of 42.32 emu/g. They showed concentration-dependent DPPH scavenging and no significant cytotoxicity or hemolysis up to 10 µg/mL. In vitro, IONPs improved motor performance, boosted antioxidants, and reduced apoptosis in dopamine neurons.ConclusionBiosynthesized IONPs offer promise as a complementary PD therapy by mitigating motor deficits and neurochemical damage.

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