Parkinson hastalığı olan hastaların EEG sinyallerindeki alfa ritminin faz ortalama dalga boyu bilişsel bozuklukla birleşti.

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ObjectiveTo investigate the changes of phase average wavelength of alpha rhythm in different brain regions of patients with Parkinson's Disease (PD) during awake period with eyes closed.MethodsThis study included 54 patients with PD and 30 normal controls. The PD patients were divided into a PD-cognitive normal group (PD-NC) and a PD-cognitive impairment group (PD-CI) based on Mini-Mental State Examination (MMSE) scores. The electroencephalography signals were decomposed at different scales using the Gauss continuous wavelet transform method. The phase average wavelength of the ninth scale (corresponding to the alpha rhythm) was extracted using the conditional sampling and phase averaging method. The alpha-band wavelengths of the background rhythm of different leads were compared between groups. Additionally, the correlation between the wavelength of the ninth scale and MMSE and Montreal Cognitive Assessment (MoCA) scores in PD patients was analyzed.ResultsThere were significant differences in phase average wavelength at scale nine in each lead among the three groups (P ConclusionsThe phase average wavelength of the alpha rhythm in PD patients was longer than that in normal controls, indicating that the alpha rhythm of PD patients was slowed down. With the deterioration of cognitive function, the alpha rhythm of PD patients gradually slowed down.SignificanceThe phase average wavelength of the electroencephalography alpha rhythm may become a new parameter for the evaluation of cognitive impairment.

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