Region-Specific Information-Theoretic Feature Representation of Wearable Plantar Insole Signals for Parkinson's Disease Gait Assessment.

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Parkinson's disease (PD) is associated with gait impairment, bilateral asymmetry, and increased gait variability, highlighting the need for objective and interpretable wearable gait assessment. Plantar insole recordings directly capture foot-ground loading, but their use in PD assessment is often limited by global or low-order descriptors that do not fully represent regional loading organization. This study proposes a region-specific information-theoretic framework for PD gait assessment using wearable plantar-pressure insoles. Bilateral plantar insole signals were reorganized into five anatomical regions: heel, rearfoot, midfoot, forefoot, and toe. Self-information index (SII), Shannon entropy (EN), negentropy (NEG), sample entropy (SEN), and Kullback-Leibler divergence (KL) features were extracted to characterize self-information fluctuation, probabilistic uncertainty, non-Gaussian organization, temporal irregularity, and directional distributional discrepancy in plantar-pressure dynamics. The resulting feature representation was evaluated at gait-cycle, walking-recording, and subject-independent levels using conventional classifiers, ablation analysis, subject-balanced cycle aggregation, and an information-theoretic three-dimensional feature-space rule model (ITFS-RM). KNN achieved an accuracy of 0.9668 at the gait-cycle level, and MLP achieved an accuracy of 0.9344 at the walking-recording level. Under stricter subject-independent evaluation, the accuracy was 0.8475, and subject-balanced-cycle aggregation achieved an accuracy of 0.8655. Region-specific analysis and ablation experiments showed spatially heterogeneous HC-PD differences, with the toe region showing the most consistent contribution. SII, KL, and NEG provided stable discriminative contributions, particularly in toe-related and regional-transition features. ITFS-RM provided explicit feature combinations, value ranges, and spatial rule boundaries for interpretable walking-recording level and subject-grouped separation. These results support region-specific information-theoretic analysis as an interpretable representation of plantar-pressure dynamics for PD gait assessment and emphasize the need for subject-wise validation when repeated walking recordings are available.

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