Fare kategori öğrenmesini destekleyen medial prefrontal korteks, dorsomedial striatum ve dorsal hipokampus arasındaki etkileşimler

Araştırma özeti

Aşağıdaki metin kaynak makalenin lisansı doğrulanmış orijinal özetidir. cc by

Categorization creates memory representations that are efficient, generalizable, and robust to noise. Multiple brain regions have been implicated in categorization, including the prefrontal cortex, striatum, and hippocampus; however, few studies have examined how these regions interact during category learning. We recorded neural activity in the medial prefrontal cortex (PFC), dorsomedial striatum (DMS), and dorsal hippocampus (HPC) while rats learned to categorize distributions of visual stimuli. We found a learning-related shift in contributions from the PFC (with DMS→PFC theta (4-10Hz) interactions) to the HPC (with HPC→DMS and bidirectional PFC-HPC theta interactions). Decision-making depended on DMS and HPC spiking, as well as the PFC→HPC→DMS pathway. Our results provide a framework that characterizes how the PFC-DMS-HPC network interacts during category learning. This is informative for multiple neurological disorders that affect category learning, including Parkinson’s Disease, autism, and dementia. Highlights - Rats learned to categorize distributions of visual stimuli. - Early training sessions relied on PFC spiking and DMS→PFC theta interactions. - After learning, contributions shifted to HPC spiking, HPC→DMS interactions, and bidirectional PFC-HPC interactions. - Decision-making depended on DMS and HPC spiking and PFC→HPC→DMS interactions. Graphical Abstract

İlgili konular