T hücre infiltrasyonunun inhibisyonu ve çözünür TNF sinyallemesi Parkinson hastalığının alfa-sinüklein aşırı eksprese eden fare modelinde nöroprotektiftir.

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Abstract Modulation of the neuroinflammatory response is emerging as an interesting approach for the treatment of Parkinson´s disease (PD). In this study we have used an adeno-associated virus (AAV9) to overexpress alpha-synuclein (αSyn) in the substantia nigra pars compacta of mice to induce a dose-dependent neuronal loss. Our results show that αSyn overexpression induces CD4 + T cell infiltration with a Th1 (IFNγ + TNFα + ) phenotype in the ventral midbrain. Inhibiting T cell infiltration with fingolimod (FTY720) or blocking soluble TNF signaling with XPro1595 improved motor function and preserved dopaminergic neurons. These treatments showed therapeutic efficacy in a chronic mouse model generated with lower AAV9 titers, highlighting the potential of targeting neuroinflammation for the treatment of PD. Our findings suggest that CD4 + T cells contribute to αSyn-induced neurodegeneration and that immune modulation may be a viable therapeutic strategy and support further exploration of neuroinflammation-targeting therapies in PD.

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