ALS'yi Yeniden Tanımlamak: Büyük ölçekli proteomik profilleme, bağışıklık, kas, metabolik ve beyin tutulumu ile uzun süreli bir tanı öncesi faz ortaya koymaktadır.

Redefining ALS: Large-scale proteomic profiling reveals a prolonged pre-diagnostic phase with immune, muscular, metabolic, and brain involvement

Homann J, Korologou-Linden R, Viallon V, Morgan S, Dobricic V, Deecke L, Schessner JP, Smith-Byrne K, Birtles D, Zhao Y, Wuu J, Artaud F, Hajizadah F, Huerta JM, Ohlei O, Lebedev M, Kolijn PM, Guevara M, Jimenez-Zabala A, Sánchez MJ, Trobajo-Sanmartín C, Colorado-Yohar SM, Alonso-Martín S, Petrova D, Sieri S, Berger K, Peters S, Wareham N, Kaaks R, Travis RC, Vermeulen RCH, The Global Neurodegeneration Proteomics Consortium (GNPC), Tzoulaki I, Elbaz A, Mann M, Sacerdote C, Masala G, Katzke V, Benatar M, Bertram L, Middleton L, Riboli E, Gunter MJ, Ferrari P, Robinson O, Lill CM.

· 2025-08-28

DOI: 10.1101/2025.08.20.25334061