Yaygın bir PD-Risk GBA1 Varyant Disrupts LIMP2 Etkileşimi, Impairs Glucocerebrosidase Fonksiyonu ve Lysozomal ve Mitokondrial Disfonksiyonu Sürüyor

A Common PD-Risk <i>GBA1</i> Variant Disrupts LIMP2 Interaction, Impairs Glucocerebrosidase Function, and Drives Lysosomal and Mitochondrial Dysfunction

Davis OB, Kung JE, Davis SS, Ghosh R, Andrews SV, Gould NS, Kluss JH, Thomsen E, Agam M, Coan JP, Maloney MT, Nguyen AH, Nguyen HN, Propson NE, Lozano EI, Yuan T, Xa K, Sperberg RAP, Jain S, Lawrence R, Ullman JC, Balasundar S, Benton HP, Petkovic M, Qerqez AN, Wang X, Zhu S, Di Paolo G, Kariolis MS, Mahon CS, Arguello A, Vocadlo DJ, Cookson MR, Suh JH, Rougé L, Henry AG.

· 2025-09-02

DOI: 10.1101/2025.08.28.672891