Parkinson Hastalığı Olan Hastalarda Cihaz Destekli Terapilerin Yaşam Kalitesine Etkisi. Karşılaştırmalı Çok Merkezli Gözlemsel Bir Çalışma.

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Abstract Background and objective:Device aided-therapies (DATs) improve health-related quality of life (HRQoL) in patients with Parkinson´s disease (PwP). However, no studies comparing all DATs have been conducted to date. Our aim was to compare the effect of different DATs on HRQoL and other disease-related variables in PwP.Patients and Methods:Data from baseline (V1) and the 6-month follow-up visit (V3.6M) were collected from a descriptive, observational, prospective, multicenter, clinical registry conducted in Spain entitled DATs-PD GETM Spanish Registry. The primary endpoint was the change from V1 to V3.6M in the 39-item Parkinson's Disease Questionnaire (PDQ-39) total score. Relative change (RC) and Cohen´s d (d) effect were applied. The effect over many other variables was also analyzed.ResultsHRQoL improved significantly in the entire cohort (N = 137) with a moderate decrease of 13.4% in the PDQ-39 total score (from 58.9 ± 22.9 at V1 to 51.0 ± 26.8 at V3.6M; d = 0.51; p ConclusionHRQoL improved in PwP after being treated with a DAT.

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