Parkinson Hastalığında PINK1 Mutasyonları ile İlişkili Mekanizmalar

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Abstract Parkinson’s disease (PD) is a widespread and progressively debilitating neurodegenerative disorder, with its global prevalence steadily increasing. Central to its pathogenesis is the PINK1 gene (PTEN-induced putative kinase 1), which plays a pivotal role in mitochondrial function and protecting cells from oxidative stress-induced apoptosis. This review explores the complex relationship between PINK1 mutations and PD, highlighting their involvement in key pathogenic mechanisms. It discusses how these mutations contribute to mitochondrial dysfunction, alterations in phosphorylation pathways, impaired autophagy, and heightened sensitivity to oxidative stress. These insights lay the groundwork for future research and therapeutic approaches, aiming to address the urgent need for effective PD interventions.

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