Erken evre Parkinson hastalığının substantia nigrasındaki demirin uzunlamasına değişiklikleri

Araştırma özeti

Aşağıdaki metin kaynak makalenin lisansı doğrulanmış orijinal özetidir. cc0

A bstract Background Higher iron occurs in the substantia nigra in Parkinson’s disease (PD), but its behavior over time is poorly understood. Objective To determine if nigral iron measured by quantitative susceptibility MRI can track progression of early stages of PD. Methods Thirty-four early-stage PD patients (disease duration Results Of five clinic metrics and five regional iron measures, only MDS-UPDRS II (p = 0.046) and SNc iron (p = 0.004) showed significant changes for PD subjects in the one-year epoch. The changes of SNc iron also were correlated with changes of MDS-UPDRS II (p = 0.005). Conclusion Nigral iron content measured by zero-referencing is sensitive for tracking disease progression in early-stage PD.

İlgili konular