Parkinson Hastalığı Olan Hastalarda Derin Venöz Tromboz Riski: Gözlemsel Çalışmaların Sistematik Bir İncelemesi ve Meta-Analizi

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Background: Parkinson's disease (PD) may increase the risk of deep venous thrombosis (DVT) through immobility, autonomic dysfunction, and perioperative factors. However, the magnitude of this association remains uncertain. We performed a systematic review and meta-analysis to evaluate DVT risk in patients with PD. Methods: PubMed/MEDLINE, Embase, Cochrane Library, and Google Scholar were searched from inception to July 1, 2026. Observational studies comparing DVT risk in adults with PD versus controls were included. Pooled risk ratios (RRs) and 95% confidence intervals (CIs) were calculated using a random-effects model. Prespecified subgroup analyses evaluated study design, geographic region, and clinical setting. Results: Sixteen studies comprising 819,514 participants met inclusion criteria; 14 studies involving 800,040 participants and 2,176 DVT events contributed to the quantitative synthesis. PD was associated with a significantly increased DVT risk (RR 2.23, 95% CI 1.41-3.53; p<0.001), with substantial heterogeneity (I²=67.2%). The strongest associations were observed in nonsurgical cohorts (RR 6.07, 95% CI 3.20-11.49) and Asian populations (RR 6.04, 95% CI 3.26-11.19). Conclusions: PD is associated with a significantly increased risk of DVT. Enhanced risk stratification and further evaluation of thromboprophylaxis strategies may be warranted, particularly in medically managed nonsurgical patients.

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