Akupunktur Parkinson Hastalığında Motor-Network Fonksiyonel Bağlanmayı Modüle Ediyor: Randomize Şem Kontrollü bir fMRI Denemesi

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Abstract Whether acupuncture produces specific neural effects in Parkinson’s disease (PD) remains unclear. In this randomized sham-controlled trial, 78 PD patients received verum (VA) or sham (SA) acupuncture for 8 sessions over 4 weeks (8-week follow-up). The primary outcome was UPDRS-III change at week 4; secondary outcomes included NMSS and PDQ-39. Resting-state fMRI assessed seed-to-whole-brain functional connectivity (FC). VA showed greater UPDRS-III improvement than SA at week 4 (between-group difference − 6.4, 95% CI − 9.9 to − 2.9; p 

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