Parkinson Hastalığı için DTI: Sistematik İnceleme ve Meta-Analiz için Bir Protokol

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Abstract Background: There is no robust biological marker for the diagnosis of Parkinson's disease, and most of them are diagnosed until motor symptoms develop, which may affect the early intervention and prognosis Objective: To evaluate the diagnostic value of different parameter values of DTI in PD.Methods and analysis: We will systematically search the cochrane, pubmed, and embase databases, but we only consider observational studies and English studies. The main outcomes are DTI parameters, including FA, MDC, and ADC. We will evaluate the quality of the included studies through the NOS scale, and the data synthesis will be analyzed by revman5.3.Discussion: This systematic review will integrate all relevant DTI observation results on PD imaging, and evaluate whether DTI can be used as a biological marker for the diagnosis of PD. The review results will provide a useful reference for the diagnosis of PDSystematic review registration: The protocol has been registered at the International Platform of Registered Systematic Review and Meta-analysis Protocols(INPLASY202070098).

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