Nörodejeneratif Bozukluklarda Yeni Enzim Hedeflerinin Biyokimyasal Rolünün Açıklanması

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Introduction: Neurodegenerative disorders, characterized by progressive neuronal loss, remain a significant clinical challenge due to their multifactorial etiology. While numerous enzymes have been implicated in their pathogenesis, there remains a knowledge gap regarding the precise biochemical roles of several novel enzyme targets. Methods: This study encompassed a multi-pronged approach, involving patient-derived samples from Alzheimer's and Parkinson's cases (n=156), an ALS mouse model (n=50), and a CRISPR-Cas9 edited Huntington's Disease zebrafish model (n=100). Enzyme activity assays, localization microscopy, and interaction pathway analyses were conducted. Results: Elevated Aminotransferases activity was observed in 78% of Alzheimer's samples compared to controls (pConclusion: Mine findings highlight the pivotal role of novel enzyme targets in neurodegenerative disorders, offering potential avenues for early detection and therapeutic interventions. The intricate interplay of these enzymes with known disease pathways underscores the need for an integrated approach to understand disease mechanisms holistically.

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